Evidence map›Paper›PMID 41862642›Full record

ArticleThe EMBO journal2026

Ca²⁺ leakage is a conserved signal for non-canonical ATG8/LC3 lipidation and membrane repair.

Di Chen, Antony Fearns, Christopher J Peddie, Maximiliano G Gutierrez

Abstract read
In one paragraph

Article in The EMBO journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Di ChenHost Pathogen Interactions In Tuberculosis Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK. di.chen@crick.ac.uk.ORCID http://orcid.org/0000-0002-2186-7717
Antony FearnsHost Pathogen Interactions In Tuberculosis Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
Christopher J PeddieElectron Microscopy Scientific Technology Platform, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
Maximiliano G GutierrezHost Pathogen Interactions In Tuberculosis Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK. max.g@crick.ac.uk.ORCID http://orcid.org/0000-0003-3199-0337

Funding

European Molecular Biology Organization (EMBO) ALTF 202-2023Wellcome Trust CC2081
6 · The paper itself

Abstract

Endomembrane damage of intracellular vesicles triggers signals that activate membrane repair in mammalian cells to restore homeostasis. However, the signals that drive diverse membrane repair recruitment at the individual organelle level are unknown. Here by recording Ca

Indexed as

Autophagy-Related Protein 8 FamilyCalciumCalcium SignalingCell MembraneMacrophagesMicrotubule-Associated ProteinsAutophagyEndosomal Sorting Complexes Required for TransportHumansLysosomesAutophagy-Related Protein 8 FamilyCalciumEndosomal Sorting Complexes Required for TransportGABARAPL2 protein, humanMAP1LC3A protein, humanMicrotubule-Associated ProteinsCa2+ LeakageLysosome DamageMacrophagesMembrane RepairNon‑canonical LC3 Lipidation

Identifiers

PMID41862642
PMCPMC13144738

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.