Trial reportScientific reports2026
Preliminary efficacy of cognitive multisensory rehabilitation for neuropathic pain in chronic spinal cord injury: a phase I randomized controlled trial.
Trial report in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04706208 (Identifying Body Awareness-related Brain Network Changes During Cognitive Multisensory Rehabilitation for Reduced Neuropathic Pain in People With Spinal Cord Injury), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Identifying Body Awareness-related Brain Network Changes During Cognitive Multisensory Rehabilitation for Reduced Neuropathic Pain in People With Spinal Cord Injury
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Neuropathic pain affects 69% of adults with spinal cord injury (SCI) and responds poorly to current treatments. Emerging evidence suggests that impaired mental body representations (MBR) may contribute to neuropathic pain. The parietal operculum and insula, key regions for pain perception and body awareness, show disrupted connectivity after SCI. We aimed to identify changes in brain function, neuropathic pain, and sensorimotor function after Cognitive Multisensory Rehabilitation (CMR) vs. usual care. CMR is a physical therapy which improves MBR. In this Phase I randomized delayed-treatment trial, 26 adults with SCI-related neuropathic pain were randomized to either 6 weeks of immediate CMR (group A), with 6-week + 1-year follow-up; or a 6-week observational period + 6-week CMR + 1-year follow-up (Group B). We assessed neuropathic pain intensity, sensorimotor function, resting-state and task-based fMRI. Neuropathic pain significantly decreased after CMR in group A + B (Numerical Pain Rating Scale, highest pain change: -4.92 ± 2.92 points, d = -1.68; average pain − 4.12 ± 2.23 points, d=-1.84), and sensorimotor function improved, while no changes followed the observational period. Benefits were maintained at one year. Post-CMR fMRI revealed stronger resting-state parietal operculum connectivity, and enhanced activation in pain- and MBR-related brain regions during a toe sensation task. Results suggest preliminary CMR efficacy for neuropathic pain reduction and functional improvement.Clinical Trial registration: ClinicalTrials.gov, NCT04706208; first registration 08/01/2021; first participant enrolled 09/01/2021.
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