ArticleNature communications2026
Parvalbumin-positive neurons in the medial septum participate in the formation of hippocampal-dependent spatial memory.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
GABAergic medial septal neurons play a key role in regulating hippocampus-dependent spatial memory, but the underlying mechanisms are not yet fully understood. In male mice, we establish an object-place recognition impairment model using an acute sleep deprivation protocol. Here we show that parvalbumin-positive neurons in the medial septum regulate object-location memory specificity during encoding by modulating hippocampal place cell population activity. Using in vivo electrophysiology combined with optogenetics, we characterize the role of medial septal parvalbumin-positive neurons in object-place recognition during memory encoding. Preference for objects relocated to novel positions parallels directional shifts in place fields of remapping neuronal populations, as well as decreased co-activity among place cells in dorsal CA1 during the encoding phase. Activating medial septal parvalbumin-positive neurons during memory encoding rescues object-place recognition impairments. These findings suggest that parvalbumin-positive neurons in the medial septum play a causal role in object-place recognition memory.
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