Evidence map›Paper›PMID 41862465›Full record

ArticleNature communications2026

Functional and structural basis of a negative allostery within GABA

Cangsong Shen, Hongyang Ding, Shenlan Zhang, Chanjuan Xu, Binqian Zou, Suyu Ji, Yi-Ru Liu, Yizhong Li, Rui Zhou, Jiayin Liang and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Cangsong Shen *Key Laboratory of Molecular Biophysics of MOE, International Research Center for Sensory Biology and Technology of MOST, College of Life Science and Technology, Huazhong University of Science and Technology (HUST), Wuhan, China.
Hongyang Ding *Key Laboratory of Molecular Biophysics of MOE, International Research Center for Sensory Biology and Technology of MOST, College of Life Science and Technology, Huazhong University of Science and Technology (HUST), Wuhan, China.
Shenlan Zhang *Bioland Laboratory, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China.
Chanjuan Xu *Key Laboratory of Molecular Biophysics of MOE, International Research Center for Sensory Biology and Technology of MOST, College of Life Science and Technology, Huazhong University of Science and Technology (HUST), Wuhan, China.ORCID http://orcid.org/0000-0002-5640-1896
Binqian Zou *State Key Laboratory of Respiratory Disease, Center for Biomedical Digital Science, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, GIBH-CUHK Joint Research Laboratory on Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Suyu JiDepartment of Pathology of Sir Run Run Shaw Hospital, Department of Pharmacology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.
Yi-Ru LiuKey Laboratory of Molecular Biophysics of MOE, International Research Center for Sensory Biology and Technology of MOST, College of Life Science and Technology, Huazhong University of Science and Technology (HUST), Wuhan, China.ORCID http://orcid.org/0009-0005-7816-3760
Yizhong LiKey Laboratory of Molecular Biophysics of MOE, International Research Center for Sensory Biology and Technology of MOST, College of Life Science and Technology, Huazhong University of Science and Technology (HUST), Wuhan, China.
Rui ZhouKey Laboratory of Molecular Biophysics of MOE, International Research Center for Sensory Biology and Technology of MOST, College of Life Science and Technology, Huazhong University of Science and Technology (HUST), Wuhan, China.
Jiayin LiangState Key Laboratory of Respiratory Disease, Center for Biomedical Digital Science, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, GIBH-CUHK Joint Research Laboratory on Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Dan-Dan ShenDepartment of Pathology of Sir Run Run Shaw Hospital, Department of Pharmacology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.
Yuxuan LiuKey Laboratory of Molecular Biophysics of MOE, International Research Center for Sensory Biology and Technology of MOST, College of Life Science and Technology, Huazhong University of Science and Technology (HUST), Wuhan, China.ORCID http://orcid.org/0009-0007-0799-3227
Xuan ChenKey Laboratory of Molecular Biophysics of MOE, International Research Center for Sensory Biology and Technology of MOST, College of Life Science and Technology, Huazhong University of Science and Technology (HUST), Wuhan, China.
Philippe RondardInstitut de Génomique Fonctionnelle (IGF), University of Montpellier, CNRS, INSERM, Montpellier, France.ORCID http://orcid.org/0000-0003-1134-2738
Jun HeState Key Laboratory of Respiratory Disease, Center for Biomedical Digital Science, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, GIBH-CUHK Joint Research Laboratory on Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China. he_jun@gibh.ac.cn.ORCID http://orcid.org/0000-0003-0270-9729
Yan ZhangDepartment of Pathology of Sir Run Run Shaw Hospital, Department of Pharmacology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China. zhang_yan@zju.edu.cn.ORCID http://orcid.org/0000-0003-2189-0244
Jean-Philippe PinInstitut de Génomique Fonctionnelle (IGF), University of Montpellier, CNRS, INSERM, Montpellier, France. jean-philippe.pin@igf.cnrs.fr.ORCID http://orcid.org/0000-0002-1423-345X
Jianfeng LiuKey Laboratory of Molecular Biophysics of MOE, International Research Center for Sensory Biology and Technology of MOST, College of Life Science and Technology, Huazhong University of Science and Technology (HUST), Wuhan, China. jfliu@mail.hust.edu.cn.ORCID http://orcid.org/0000-0002-0284-8377

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

G protein coupled receptors (GPCRs) oligomerization may allow signal integration from different GPCR units. The GABA

Indexed as

Protein MultimerizationReceptors, GABA-BAllosteric RegulationAnimalsBaclofenCryoelectron Microscopygamma-Aminobutyric AcidHEK293 CellsHumansModels, MolecularMutationNeuronsBaclofengamma-Aminobutyric AcidReceptors, GABA-B

Identifiers

PMID41862465
PMCPMC13168656

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.