Evidence map›Paper›PMID 41862459›Full record

ArticleNature communications2026

Formaldehyde hydrazone as a methyl reagent for nickel-catalyzed cross-coupling methylation of aryl and heteroaryl electrophiles.

Daliah Farajat, Léa Philippe, Faraz Alaghemand, Anastasiia Afanasenko, Durbis J Castillo-Pazos, Juan D Lasso, Yiram Kim, Evan F W Chen, Joaquín Barroso-Flores, Rustam Z Khaliullin and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Daliah FarajatDepartment of Chemistry, and FQRNT Centre for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke Street West, Montreal, Quebec, Canada.ORCID http://orcid.org/0009-0005-1231-8440
Léa PhilippeDepartment of Chemistry, and FQRNT Centre for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke Street West, Montreal, Quebec, Canada.
Faraz AlaghemandDepartment of Chemistry, and FQRNT Centre for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke Street West, Montreal, Quebec, Canada.ORCID http://orcid.org/0009-0002-6951-3544
Anastasiia AfanasenkoDepartment of Chemistry, and FQRNT Centre for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke Street West, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0001-7234-8290
Durbis J Castillo-PazosDepartment of Chemistry, and FQRNT Centre for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke Street West, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0003-1309-6366
Juan D LassoDepartment of Chemistry, and FQRNT Centre for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke Street West, Montreal, Quebec, Canada.
Yiram KimDepartment of Chemistry, and FQRNT Centre for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke Street West, Montreal, Quebec, Canada.
Evan F W ChenDepartment of Chemistry, and FQRNT Centre for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke Street West, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0002-2120-7161
Joaquín Barroso-FloresInstitute of Chemistry, National Autonomous University of Mexico, Ciudad Universitaria, CDMX, México, Mexico.ORCID http://orcid.org/0000-0003-0554-7569
Rustam Z KhaliullinDepartment of Chemistry, and FQRNT Centre for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke Street West, Montreal, Quebec, Canada. rustam.khaliullin@mcgill.ca.ORCID http://orcid.org/0000-0002-9073-6753
Chao-Jun LiDepartment of Chemistry, and FQRNT Centre for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke Street West, Montreal, Quebec, Canada. cj.li@mcgill.ca.ORCID http://orcid.org/0000-0002-3859-8824

Funding

Canada Research Chairs (Chaires de recherche du Canada) N/AGouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (Conseil de Recherches en Sciences Naturelles et en Génie du Canada) N/A
6 · The paper itself

Abstract

Methyl groups play a vital role in pharmaceuticals, where their installation onto aryl and heteroaryl moieties of drug candidates can often enhance drug-target interactions. This phenomenon, termed the "magic methyl effect", has become an important tool for improving therapeutic potency during the lead optimization stages of drug development. Herein, we report a methodology for the methylation of various phenols (as tosylates) and aryl halides via a hydrazone-mediated Ni-catalyzed cross-coupling reaction, employing formaldehyde hydrazone as the methyl reagent. The reaction delivers moderate to good yields across a structurally diverse set of aryl and heteroaryl electrophiles. Experimental and computational investigations support the proposed reaction mechanism.

Identifiers

PMID41862459
PMCPMC13168639

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.