ReviewTrends in genetics : TIG2026
Replication origin flexibility: a tool to mitigate the hazards of excess replication.
Review in Trends in genetics : TIG, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
5 authors.
Funding
Abstract
Chromosome duplication is critical for genome integrity, yet inaccurate DNA synthesis can induce DNA damage and foster structural genomic variations. Cells mitigate these risks using flexible replication initiation mechanisms responsive to changes in chromatin structure, transcriptional cues, and nuclear architecture. Recent studies reveal chromatin-dependent mechanisms preventing DNA synthesis at damaged nuclear compartments while permitting replication elsewhere. To minimize replication stress, cells activate signaling cascades with dual roles: blocking replication at dormant origins to prevent over-replication during normal growth and activating dormant origins when replication is perturbed to ensure genome integrity. Here, we explore molecular pathways governing selective origin activation in response to replication stress and DNA damage. Understanding these pathways could reveal therapeutic vulnerabilities in cancer cells' altered replication landscapes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.