Evidence map›Paper›PMID 41862213›Full record

ArticleZeitschrift fur Gastroenterologie2026

Assessing the Relationship Between Steatotic Liver Disease and Barrett's Esophagus: A Cross-Sectional Analysis of 5507 Screening Participants.

Nikolaus Götz, Andreas Völkerer, Hannah Hofer, Sarah Wernly, Franz Singhartinger, Ewald Wöll, Elmar Aigner, Maria Flamm, Christian Datz, Bernhard Wernly

Abstract read
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Article in Zeitschrift fur Gastroenterologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Nikolaus GötzParacelsus Medical University, Salzburg, Austria, Salzburg.
Andreas VölkererParacelsus Medical University, Salzburg, Austria, Salzburg.
Hannah HoferParacelsus Medical University, Salzburg, Austria, Salzburg.
Sarah WernlyParacelsus Medical University, Salzburg, Austria, Salzburg.
Franz SinghartingerParacelsus Medical University, Salzburg, Austria, Salzburg.
Ewald WöllParacelsus Medical University, Salzburg, Austria, Salzburg.
Elmar AignerParacelsus Medical University, Salzburg, Austria, Salzburg.
Maria FlammParacelsus Medical University, Salzburg, Austria, Salzburg.
Christian DatzParacelsus Medical University, Salzburg, Austria, Salzburg.
Bernhard WernlyParacelsus Medical University, Salzburg, Austria, Salzburg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Barrett's esophagus (BE) is the main precursor of esophageal adenocarcinoma (~2% prevalence in Western adults). Steatotic liver disease (SLD), affecting ~25% of adults, is linked to systemic inflammation, but its relationship with BE is unclear. Methods: In the population-based Salzburg Colon Cancer Prevention Initiative (2007-2020), we analyzed 5507 asymptomatic screening participants. SLD was diagnosed by ultrasound and classified as MASLD or MetALD; BE was confirmed endoscopically and histologically. Associations were assessed using multivariable logistic regression adjusting for demographic, metabolic, and clinical factors. Results: SLD was present in 2550 participants and clustered with diabetes and metabolic syndrome. BE was found in 62 individuals (1.0% without SLD, 1.5% with MASLD, 1.1% with MetALD; P = 0.28). After adjustment, MASLD (OR 1.28; 95% CI 0.74-2.21) and MetALD (OR 0.66; 95% CI 0.16-2.85) were not significantly associated with BE. Female sex was protective (OR 0.26; 95% CI 0.13-0.50), while hiatal hernia increased BE risk (OR 2.05; 95% CI 1.16-3.60). Conclusion: In this population-based cohort, MASLD and MetALD were not clearly associated with BE. Current data do not support incorporating SLD status into BE screening algorithms, although modest risk increases cannot be ruled out.

Indexed as

Barrett EsophagusFatty LiverAgedComorbidityCross-Sectional StudiesFemaleGermanyHernia, HiatalHumansMaleMass ScreeningMiddle AgedPrevalenceRisk Factors

Identifiers

PMID41862213
PMCPMC13288400

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