ArticleJornal de pediatria
Persistent candidemia in pediatrics: exploring risk factors.
Article in Jornal de pediatria. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePersistent candidemia (PC) in children can lead to unfavorable outcomes. However, its risk factors and clinical impact remain poorly understood. This study aimed to identify risk factors associated with PC in pediatric patients.
methodWe conducted a retrospective analysis of 141 children (0-17 years) diagnosed with candidemia at a children's hospital in Brazil between 2016 and 2022. Clinical data were collected from medical records. Microorganisms were identified by MALDI-TOF MS, tested for biofilm production, and sensitivity profile. Molecular typing was performed on the three most prevalent species, and ERG11 mutation screening was carried out on fluconazole-resistant isolates.
resultsPC was identified in 34.8% (n = 49) patients. Independent risk factors included early non-removal of the central venous catheter, parenteral nutrition, and cancer. The overall 30-day mortality was 23.4%, and the candidemia-related mortality was 16.3%. C. parapsilosis was the prevalent species. All isolates except one produced biofilm. One isolate of C. tropicalis, which had the missense mutation Y257H in ERG11, was resistant to fluconazole. Isolates showed high genetic diversity.
conclusionsPC was associated with host factors and clinical management rather than aspects of the etiological agent, highlighting the importance of early patient monitoring.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.