Evidence map›Paper›PMID 41862169›Full record

ArticleJornal de pediatria

Metabolic dysfunction-associated steatotic liver disease, biomarkers, and cardiovascular risk factors in children with excess weight.

Elisabeth A Machado, Beatriz L C Themistocles, Jorge M R Teixeira, Fernanda M G Jannuzzi, Geísa Tomaz, Cecilia L Oliveira, Isabel R Madeira, Carlos Terra, Maria das Graças C Souza, Alexandra Monteiro and 3 more

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Article in Jornal de pediatria. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Elisabeth A MachadoUniversidade do Estado do Rio de Janeiro, Instituto de Aplicação Fernando Rodrigues da Silveira, Rio de Janeiro, RJ, Brazil; Universidade do Estado do Rio de Janeiro, Centro Biomédico, Laboratório de Pesquisa Clínica e Experimental em Biologia Vascular, Rio de Janeiro, RJ, Brazil; Universidade do Estado do Rio de Janeiro, Postgraduate Program in Clinical and Experimental Physiopathology, Rio de Janeiro, RJ, Brazil. Electronic address: bethamachado6@gmail.com.
Beatriz L C ThemistoclesUniversidade do Estado do Rio de Janeiro, Postgraduate Program in Clinical and Experimental Physiopathology, Rio de Janeiro, RJ, Brazil.
Jorge M R TeixeiraUniversidade do Estado do Rio de Janeiro, Instituto de Nutrição, Rio de Janeiro, RJ, Brazil.
Fernanda M G JannuzziUniversidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Department of Internal Medicine, Endocrinology Care Teaching Unit, Rio de Janeiro, RJ, Brazil.
Geísa TomazUniversidade do Estado do Rio de Janeiro, Postgraduate Program in Clinical and Experimental Physiopathology, Rio de Janeiro, RJ, Brazil.
Cecilia L OliveiraUniversidade do Estado do Rio de Janeiro, Instituto de Nutrição, Rio de Janeiro, RJ, Brazil.
Isabel R MadeiraUniversidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Department of Pediatrics, Rio de Janeiro, RJ, Brazil.
Carlos TerraUniversidade do Estado do Rio de Janeiro, Gastroenterology Department, Hepatology Unit, Rio de Janeiro, RJ, Brazil.
Maria das Graças C SouzaUniversidade do Estado do Rio de Janeiro, Centro Biomédico, Laboratório de Pesquisa Clínica e Experimental em Biologia Vascular, Rio de Janeiro, RJ, Brazil.
Alexandra MonteiroUniversidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Department of Radiology, Rio de Janeiro, RJ, Brazil.
Eliete BouskelaUniversidade do Estado do Rio de Janeiro, Centro Biomédico, Laboratório de Pesquisa Clínica e Experimental em Biologia Vascular, Rio de Janeiro, RJ, Brazil.
Marise E MarsillacUniversidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Department of Pediatrics, Rio de Janeiro, RJ, Brazil.
Paulo F Collett-SolbergUniversidade do Estado do Rio de Janeiro, Centro Biomédico, Laboratório de Pesquisa Clínica e Experimental em Biologia Vascular, Rio de Janeiro, RJ, Brazil; Universidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Department of Internal Medicine, Discipline of Endocrinology, Rio de Janeiro, RJ, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe increasing prevalence of metabolic dysfunction associated with steatotic liver disease (MASLD) is consistent with the global obesity epidemic. The aim of the study was to investigate the presence of MASLD in a high-risk group of children and to compare cardiovascular risk factors between the groups with and without MASLD, in addition to investigating potential biomarkers.

methodsThis cross-sectional study was carried out at a public institution with thirty-eight patients (19 girls, 13.2 ± 2.7 y) with excess weight. Blood pressure (BP), abdominal fat, carotid intima-media thickness (CIMT), and blood biochemistry were evaluated. Steatosis was assessed by the controlled attenuation parameter (CAP) obtained via transient elastography, and the participants were grouped as ¨Non-Steatosis¨ (n = 24) and ¨Steatosis¨ (n = 14).

resultsThe "Steatosis group" showed higher BP (Z SBP 1.56 vs. -0.25; Z DBP 1.38 vs. 0.07; p = 0.0001), BMI (z-BMI 3.48 vs. 2.39; p < 0.0001), right CIMT (0.07 vs. 0.06 cm; p = 0.013), basal insulin (41 vs. 14 mcUI/l; p < 0.0001), and HOMA-IR (8.2 vs. 3.1; p < 0.0001), and lower adiponectin (2.75 vs. 6.46 µg/ml; p = 0.004) compared to the "Non-Steatosis" group even after z-BMI adjustments. ROC curves indicated adiponectin (cutoff ≤ 4.5 μg/mL) and insulin (cutoff ≥ 22 mcIU/mL) as biomarkers of steatosis.

conclusionIn pediatric age with excess weight, hepatic steatosis was associated with higher BP, severe obesity, and worse glycemic profile. Low adiponectin and high insulin levels appeared as possible biomarkers of MASLD. The study reinforces the need for children with obesity and a worse metabolic profile to be investigated for early diagnosis of MASLD.

Indexed as

Cardiovascular DiseasesFatty LiverHeart Disease Risk FactorsNon-alcoholic Fatty Liver DiseasePediatric ObesityAdiponectinAdolescentBiomarkersCarotid Intima-Media ThicknessChildCross-Sectional StudiesFemaleHumansMaleRisk FactorsAdiponectinBiomarkersAdiponectinInsulinMASLDPediatric obesityTransient elastography

Identifiers

PMID41862169
PMCPMC13084364

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.