Evidence map›Paper›PMID 41862028›Full record

ArticleThe Journal of infection2026

Selective elimination of myeloid HIV reservoirs by targeting pro-survival pathways.

Min Li, Baichao Sun, Laurie J Minze, Edward A Graviss, Matthew Vasquez, Hong Zhao, Benjamin B Gelman, Min Chen, Jin Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infection, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Min LiImmunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston, TX 77030, USA.
Baichao SunImmunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston, TX 77030, USA.
Laurie J MinzeImmunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston, TX 77030, USA.
Edward A GravissDepartment of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston, TX 77030, USA.
Matthew VasquezDepartment of System Medicine and Bioengineering, Houston Methodist Research Institute, Houston, TX 77030, USA.
Hong ZhaoDepartment of System Medicine and Bioengineering, Houston Methodist Research Institute, Houston, TX 77030, USA.
Benjamin B GelmanDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Min ChenDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
Jin WangImmunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston, TX 77030, USA; Department of Surgery, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA. Electronic address: jinwang@houstonmethodist.org.

Funding

Targeting the HIV-1 Reservoir in Myeloid CellsR01MH127979 · NIMH · METHODIST HOSPITAL RESEARCH INSTITUTE · PI WANG, JIN · 2021 to 2025
$2.4M
Regulation of Cell Death in HIV ReservoirsR01AI176558 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI JIN WANG · 2023 to 2026
$2.4M
NIAID NIH HHS R01 AI176558NIMH NIH HHS R01 MH127979
6 · The paper itself

Abstract

objectivesHIV reservoirs in myeloid cells, including tissue-resident macrophages, persist despite antiretroviral therapy, hindering viral eradication. We have tested an approach for HIV clearance through selective elimination of host cells harboring replication-competent HIV (SECH), by inhibition of autophagy and anti-apoptotic molecules during viral reactivation. Whether the SECH approach can effectively target reservoirs of the myeloid lineage is investigated.

methodsWe examined whether SECH treatments could deplete HIV-infected macrophages from HIV

resultsSECH treatments can eliminate HIV-infected macrophages from HIV

conclusionsOur data suggest that myeloid HIV reservoirs resistant to depletion display limited HIV gene expression by epigenetic repressors, and express more pro-survival genes, while targeting these mechanisms helps to promote the clearance of myeloid HIV reservoirs.

Indexed as

HIV-1HIV InfectionsMacrophagesMyeloid CellsAnimalsApoptosisAutophagyBrainGene Expression ProfilingHost-Directed TherapyHumansMiceVirus ActivationVirus LatencyVirus ReplicationApoptosisAutophagyEpigeneticsHIVTissue-resident macrophagesTranscriptome

Identifiers

PMID41862028
PMCPMC13215700

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.