ArticleNeuron2026
Soluble α2δ-1, altered in disease CSF, modulates network homeostasis and rescues deficits in a neuropsychiatric mouse model.
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Article in Neuron, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
18 authors.
Marc Dos SantosDepartment of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Marc P ForrestDepartment of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Ewa Bomba-WarczakDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Soumil DeyDepartment of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Euan ParnellDepartment of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Jessica M ChristiansenDepartment of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Seby L EdasseryDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Kun YangDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Lindsay N HayesThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jennifer M CoughlinDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Blair L EckmanDepartment of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Catherine R LammertDepartment of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
M Dolores Martin-de-SaavedraDepartment of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Maria V BarbolinaDepartment of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA.
Marco MartinaDepartment of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Akira SawaThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jeffrey N SavasDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Peter PenzesDepartment of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address: p-penzes@northwestern.edu.
Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9MStructure-Function Studies of MsvR, a Methanogen-Specific Transcriptional RegulaP20GM103640 · NIGMS · UNIVERSITY OF OKLAHOMA · PI THOMAS, LEONARD M · 2012 to 2021
$20.4MProject 3P50MH094268 · NIMH · JOHNS HOPKINS UNIVERSITY · PI PLETNIKOV, MIKHAIL V · 2011 to 2020
$19.9MProject 3P50MH136297 · NIMH · JOHNS HOPKINS UNIVERSITY · PI Akira Sawa · 2024 to 2026
$12.8MProtein Production and Characterization CoreP30GM145423 · NIGMS · UNIVERSITY OF OKLAHOMA · PI ANN H WEST · 2022 to 2026
$6.9MSynaptic and dendritic dysfunction in psychiatric disordersR01MH097216 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PENZES, PETER · 2012 to 2021
$6.1MNeuronal excitability and copy number variation disordersR01NS114977 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PENZES, PETER, SAVAS, JEFFREY NICHOLAS · 2020 to 2024
$3.2MHigh throughput marker for cognitive deficit: cellular autofluorescenceR01MH107730 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2018 to 2022
$3.0MNKCC1-KCC2 system modulation in rodent models relevant for psychiatric disordersR56MH135860 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MARTINA, MARCO · 2024 to 2024
$648kNikon CSU W1 SoRa for the Center for Advanced Microscopy and Nikon Imaging Center at Northwestern UniversityS10OD032270 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARVANITIS, CONSTADINA · 2023 to 2023
$600kNCI NIH HHS P30 CA060553NIGMS NIH HHS P20 GM103640NIGMS NIH HHS P30 GM145423NIH HHS S10 OD032270NIMH NIH HHS P50 MH094268NIMH NIH HHS P50 MH136297NIMH NIH HHS R01 MH097216NIMH NIH HHS R01 MH107730NIMH NIH HHS R56 MH135860NINDS NIH HHS R01 NS114977
Abstract
Excitation-inhibition (E/I) balance depends on dynamic communication between neuronal subtypes, potentially beyond classical neurotransmission. While membrane-bound ion channels are essential for neuronal function, their potential roles as extracellular regulators of network dynamics remain largely unexplored. Here, we identify a soluble form of the voltage-gated Ca
Indexed as
Calcium ChannelsHomeostasisNerve NetSchizophreniaAnimalsDisease Models, AnimalFemaleHumansInterneuronsMaleMicePrefrontal CortexCalcium Channelscerebrospinal fluidintercellular communicationneuronal network homeostasisneuropsychiatric disorderssynaptic ectodomains
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What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.