Evidence map›Paper›PMID 41861582›Full record

ArticleInternational dental journal2026

Clinical Outcomes of Polidocanol Foam Sclerotherapy in Treatment of Sublingual Ranula.

Kexuan Li, Xiujuan Yang, Chuangqi Yu, Jiawei Zheng, Guanhuan Du, Qin Zhou

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Article in International dental journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Kexuan LiDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, College of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
Xiujuan YangDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, College of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
Chuangqi YuDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, College of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
Jiawei ZhengShanghai Key Laboratory of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, College of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Jiao Tong University, Shanghai, China; Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Guanhuan DuShanghai Key Laboratory of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, College of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Jiao Tong University, Shanghai, China; Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: dgh-09@163.com.
Qin ZhouDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, College of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Jiao Tong University, Shanghai, China. Electronic address: qin_zq@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

INTRODUCTION AND

aimsRanula is a mucus retention cyst originating from the sublingual gland, and surgical intervention has traditionally been the main treatment. However, surgery is often associated with recurrence, risk of nerve injury, and patient discomfort. Sclerotherapy using polidocanol, a low-toxicity agent, has emerged as a promising minimally invasive alternative. This study aimed to evaluate the clinical outcomes and safety of polidocanol injection therapy in patients with sublingual ranula.

methodsThis retrospective study included 34 patients with sublingual ranula who underwent intralesional injection of 3% polidocanol between December 2021 and March 2025. Some patients with large or recurrent lesions were additionally treated with pingyangmycin. Clinical data including age, sex, lesion size, symptom duration, number of injections, and follow-up time were collected. Treatment outcomes were categorized as complete resolution or unfavorable outcomes (including partial remission or recurrence). Statistical analyses were performed to identify factors associated with treatment outcomes.

resultsAmong the 34 patients, 30 (88.2%) achieved complete resolution, while 4 (11.8%) had unfavorable outcomes. Maximum lesion diameter was independently associated with treatment outcome (adjusted OR per 1-mm increase = 0.886, 95% CI: 0.742-0.982; P = .018; Firth-penalized logistic regression adjusted for age and lesion site). No serious complications were observed during a mean follow-up of 22.44 ± 14.93 months.

conclusionPolidocanol injection therapy appears to be a safe and minimally invasive option for the management of sublingual ranula, demonstrating favorable clinical outcomes and a high rate of lesion resolution in this retrospective cohort. CLINICAL RELEVANCE: Polidocanol sclerotherapy offers a conservative outpatient treatment option for sublingual ranula, providing favorable clinical outcomes with low morbidity and potentially reducing the need for surgical excision.

Indexed as

PolidocanolRanulaSclerosing SolutionsSclerotherapyAdolescentAdultFemaleHumansInjections, IntralesionalMaleRetrospective StudiesSublingual GlandTreatment OutcomeYoung AdultPolidocanolSclerosing SolutionsClinical outcomesPolidocanolSclerotherapySublingual ranula

Identifiers

PMID41861582
PMCPMC13018947

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.