Evidence map›Paper›PMID 41861024›Full record

ArticleScience advances2026

Caspase-3/7 deficiency results in enhanced intestinal inflammation and reduced tumorigenesis.

Wei Xie, Laura Wyckaert, Mike Vadi, Bruno Verstraeten, Tatyana Divert, Jef Haerinck, Riet De Rycke, Femke Baeke, Mohamed Lamkanfi, Geert Berx and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Targeting the non-coding RNA-PANoptosis axis: a novel frontier in disease diagnosis and therapy.Apoptosis : an international journal on programmed cell death · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wei XieMolecular Signaling and Cell Death Unit, VIB-UGent Center for Inflammation Research, Flanders Institute for Biotechnology, Ghent, Belgium.ORCID 0000-0001-5554-2075
Laura WyckaertMolecular Signaling and Cell Death Unit, VIB-UGent Center for Inflammation Research, Flanders Institute for Biotechnology, Ghent, Belgium.ORCID 0000-0002-8131-1585
Mike VadiMolecular Signaling and Cell Death Unit, VIB-UGent Center for Inflammation Research, Flanders Institute for Biotechnology, Ghent, Belgium.ORCID 0000-0001-5910-008X
Bruno VerstraetenMolecular Signaling and Cell Death Unit, VIB-UGent Center for Inflammation Research, Flanders Institute for Biotechnology, Ghent, Belgium.ORCID 0000-0003-3573-1463
Tatyana DivertMolecular Signaling and Cell Death Unit, VIB-UGent Center for Inflammation Research, Flanders Institute for Biotechnology, Ghent, Belgium.ORCID 0009-0006-8989-1840
Jef HaerinckDepartment of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.ORCID 0000-0001-5198-4968
Riet De RyckeDepartment of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.ORCID 0000-0001-8270-7015
Femke BaekeDepartment of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.ORCID 0009-0004-3566-658X
Mohamed LamkanfiDepartment of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
Geert BerxDepartment of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.ORCID 0000-0001-5770-2458
Adam WahidaMolecular Signaling and Cell Death Unit, VIB-UGent Center for Inflammation Research, Flanders Institute for Biotechnology, Ghent, Belgium.ORCID 0000-0002-8856-8834
Peter VandenabeeleMolecular Signaling and Cell Death Unit, VIB-UGent Center for Inflammation Research, Flanders Institute for Biotechnology, Ghent, Belgium.ORCID 0000-0002-6669-8822

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aberrant intestinal epithelial cell (IEC) death is common in inflammatory bowel disease (IBD) and related animal models. While various cell death pathways contribute to disease, the dominant modalities and their regulatory mechanisms in intestinal inflammation remain ill defined. Using the DSS colitis model, we examined the contribution of apoptosis (

Indexed as

CarcinogenesisCaspase 3Caspase 7ColitisAnimalsApoptosisCell ProliferationDextran SulfateDisease Models, AnimalInflammationInflammatory Bowel DiseasesIntestinal MucosaMiceMice, KnockoutCasp3 protein, mouseCasp7 protein, mouseCaspase 3Caspase 7Dextran Sulfate

Identifiers

PMID41861024
PMCPMC13004036

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.