Evidence map›Paper›PMID 41861019›Full record

ArticleScience advances2026

Mechanisms of CARMIL dimerization, autoinhibition, and capping protein binding.

Kyle R Barrie, Sarah Körber, Ingrid Billault-Chaumartin, Malgorzata Boczkowska, Peter J Carman, Omar El Hamoui, Johan Peränen, Guillaume Romet-Lemonne, Antoine Jégou, Pekka Lappalainen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kyle R BarrieDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-0860-1639
Sarah KörberFaculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-5077-9345
Ingrid Billault-ChaumartinUniversité Paris Cité, CNRS, Institut Jacques Monod, F-75013 Paris, France.
Malgorzata BoczkowskaDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-1677-023X
Peter J CarmanDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-6120-5507
Omar El HamouiUniversité Paris Cité, CNRS, Institut Jacques Monod, F-75013 Paris, France.ORCID 0000-0002-1493-4686
Johan PeränenFaculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-7807-3889
Guillaume Romet-LemonneUniversité Paris Cité, CNRS, Institut Jacques Monod, F-75013 Paris, France.ORCID 0000-0002-4938-1065
Antoine JégouUniversité Paris Cité, CNRS, Institut Jacques Monod, F-75013 Paris, France.ORCID 0000-0003-0356-3127
Pekka LappalainenFaculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.ORCID 0000-0001-6227-0354
Roberto DominguezDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-3186-5229

Funding

Structural-Functional Basis of Actin Cytoskeleton DynamicsR01GM073791 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI DOMINGUEZ, ROBERTO · 2005 to 2025
$7.0M
Structural-Functional Mechanisms Controlling Actin Filament Barbed and Pointed End DynamicsR01GM152412 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI DOMINGUEZ, ROBERTO · 2024 to 2025
$650k
NIGMS NIH HHS R01 GM073791NIGMS NIH HHS R01 GM152412
6 · The paper itself

Abstract

Capping protein (CP) regulates actin-based motility by blocking monomer exchange at the filament barbed end. Several proteins, including CARMIL, bind CP and allosterically weaken its affinity for the barbed end. CARMIL comprises pleckstrin homology (PH), leucine-rich repeat (LRR), helical dimerization (HD), CP-binding region (CBR), and proline-rich (PR) domains, but their roles in CP regulation remain unclear. We show that CARMIL1 is partially autoinhibited, with CBR (CARMIL1

Indexed as

Actin Capping ProteinsProtein MultimerizationAnimalsHumansModels, MolecularProtein BindingActin Capping Proteins

Identifiers

PMID41861019
PMCPMC13004031

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.