Evidence map›Paper›PMID 41861014›Full record

ArticleScience advances2026

Regulation of sodium/calcium homeostasis by BacNa

Tianyu Wu, Yongwu Li, Robin M Perelli, Yiu Yan Siu, Anna Tornatore, Josue Nataren, Xixian Jiang, Sophia DeLuca, Donald M Bers, Craig Henriquez and 2 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tianyu WuDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.ORCID 0000-0002-7341-2781
Yongwu LiDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.ORCID 0000-0002-3574-0485
Robin M PerelliDivision of Cardiology, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0002-5120-0470
Yiu Yan SiuDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Anna TornatoreDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Josue NatarenDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Xixian JiangDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.ORCID 0000-0001-5280-8894
Sophia DeLucaDepartment of Cell Biology, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0001-9432-8186
Donald M BersDepartment of Pharmacology, University of California, Davis, CA, USA.ORCID 0000-0002-2237-9483
Craig HenriquezDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Andrew P LandstromDivision of Cardiology, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0002-1878-9631
Nenad BursacDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.ORCID 0000-0002-5688-6061

Funding

Project 3 - Role of Proline Metabolism in Regulation of Mammalian Cardiomyocyte ProliferationP01HL160476 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Hesham Sadek · 2022 to 2026
$13.1M
Integrated Cellular and Tissue Engineering for Ischemic Heart DiseaseU01HL134764 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BURSAC, NENAD, KAMP, TIMOTHY J. · 2016 to 2022
$7.7M
Engineering Human Heart Tissues with Polyploid CardiomyocytesR01HL164013 · NHLBI · DUKE UNIVERSITY · PI BURSAC, NENAD · 2022 to 2025
$2.2M
In Vitro and In Situ Engineering of Fibroblasts for Cardiac RepairR01HL132389 · NHLBI · DUKE UNIVERSITY · PI BURSAC, NENAD · 2016 to 2019
$2.0M
Engineered BacNav and BacCav for Improved Excitability and ContractionR01EB032726 · NIBIB · DUKE UNIVERSITY · PI BURSAC, NENAD · 2022 to 2025
$1.9M
Engineering of Human Excitable Tissues from Unexcitable CellsR01HL126524 · NHLBI · DUKE UNIVERSITY · PI BURSAC, NENAD · 2016 to 2019
$1.9M
Investigating Mitogenic Mechanism and Therapeutic Efficacy of Adenosine Deaminase Knockout in Human and Murine CardiomyocytesF31HL162460 · NHLBI · DUKE UNIVERSITY · PI DELUCA, SOPHIA BUNNELL · 2022 to 2023
$84k
NHLBI NIH HHS F31 HL162460NHLBI NIH HHS P01 HL160476NHLBI NIH HHS R01 HL126524NHLBI NIH HHS R01 HL132389NHLBI NIH HHS R01 HL164013NHLBI NIH HHS U01 HL134764NIBIB NIH HHS R01 EB032726
6 · The paper itself

Abstract

Despite continued progress, therapies to augment contractile function and prevent arrhythmias in patients with heart failure remain limited. Here, we present a two-pronged gene therapy approach that simultaneously augments peak Na

Indexed as

CalciumGenetic TherapyHeart FailureHomeostasisSodiumSodium ChannelsAnimalsChronic DiseaseDependovirusDisease Models, AnimalGenetic VectorsHumansMiceMyocardial ContractionMyocytes, CardiacRabbitsCalciumSodiumSodium-Calcium ExchangerSodium Channels

Identifiers

PMID41861014
PMCPMC13004020

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.