Evidence map›Paper›PMID 41861003›Full record

ArticleScience advances2026

Dengue infection elicits skin tissue-resident and circulating CD8

Noor Zayanah Hamis, Justin Sg Ooi, Ka-Wai Cheung, Valerie Chew, Michaela Gregorova, Eugenia Ziying Ong, Kuan Rong Chan, Tun-Linn Thein, Yee-Sin Leo, David Chien Boon Lye and 2 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Noor Zayanah HamisEmerging Infectious Diseases Programme, Duke-NUS Medical School, Singapore, Singapore.ORCID 0009-0007-0012-0976
Justin Sg OoiEmerging Infectious Diseases Programme, Duke-NUS Medical School, Singapore, Singapore.ORCID 0000-0003-4899-8255
Ka-Wai CheungEmerging Infectious Diseases Programme, Duke-NUS Medical School, Singapore, Singapore.
Valerie ChewEmerging Infectious Diseases Programme, Duke-NUS Medical School, Singapore, Singapore.ORCID 0000-0001-8679-2659
Michaela GregorovaSchool of Biochemistry and Cellular and Molecular Medicine, University of Bristol, Bristol, UK.ORCID 0000-0003-1605-0558
Eugenia Ziying OngEmerging Infectious Diseases Programme, Duke-NUS Medical School, Singapore, Singapore.ORCID 0000-0003-2187-7058
Kuan Rong ChanEmerging Infectious Diseases Programme, Duke-NUS Medical School, Singapore, Singapore.ORCID 0000-0002-2427-671X
Tun-Linn TheinNational Centre for Infectious Diseases, Singapore, Singapore.ORCID 0000-0002-5254-032X
Yee-Sin LeoNational Centre for Infectious Diseases, Singapore, Singapore.ORCID 0000-0003-4978-5825
David Chien Boon LyeNational Centre for Infectious Diseases, Singapore, Singapore.ORCID 0000-0003-0324-0205
Eng Eong OoiEmerging Infectious Diseases Programme, Duke-NUS Medical School, Singapore, Singapore.ORCID 0000-0002-0520-1544
Laura RivinoEmerging Infectious Diseases Programme, Duke-NUS Medical School, Singapore, Singapore.ORCID 0000-0001-6213-9794

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dengue is spreading globally, and there is urgent need to define immune correlates of protection for this disease. Dengue infection first occurs in the skin following the bite of an infected mosquito; however, knowledge of host immune responses within this site remains sparse. We investigated the phenotypic, functional, and transcriptional profiles of skin and blood T cells in 73 patients with dengue and 10 healthy volunteers. We show that the skin T cell compartment undergoes marked reshaping and is strongly enriched with proliferating CD4

Indexed as

CD8-Positive T-LymphocytesDengueHospitalizationSkinAdultCD4-Positive T-LymphocytesDengue VirusFemaleHumansImmunologic MemoryLymphocyte ActivationMaleMiddle Aged

Identifiers

PMID41861003
PMCPMC13004022

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.