ArticlePloS one2026
The association between psoriasis and nonalcoholic fatty liver disease: Mediation analysis involving inflammatory biomarkers among U.S. adults.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPsoriasis has been observed to be associated with an increased risk of nonalcoholic fatty liver disease (NAFLD). However, investigating novel mediators that influence the relationship between psoriasis and NAFLD is essential, given their complex interconnection. Currently, it remains unclear whether inflammatory biomarkers play a mediating role in this association.
methodsData from adults aged 20-60 years were obtained from the National Health and Nutrition Examination Survey (NHANES), which was conducted between 2003-2006 and 2009-2014. Logistic regression was used to analyze the association between psoriasis and NAFLD across three different models. Subgroup and interaction analyses were performed to explore potential nonlinear and independent relationships between psoriasis and NAFLD. Mediation analysis was conducted to determine whether the systemic immune-inflammation index (SII) and neutrophil-to-lymphocyte ratio (NLR), two inflammatory markers, mediate the relationship between psoriasis and NAFLD.
resultsA total of 9,439 participants were included in the study, of whom 3,961 had NAFLD, with a weighted prevalence rate of 41.96%. Compared with participants without psoriasis, those with psoriasis had a greater prevalence of NAFLD, reaching 50.99%. In all three models, psoriasis was positively associated with the risk of NAFLD, and a significant dose‒response relationship was observed (p < 0.05). Mediation analysis revealed that, in the adjusted models, Ln-SII and Ln-NLR statistically mediated the association between psoriasis and NAFLD, with percentages of 8.52% and 3.58%, respectively (p < 0.05).
conclusionPsoriasis is positively associated with the occurrence of NAFLD, and the SII and NLR play key mediating roles in the relationship between psoriasis and NAFLD.
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