Evidence map›Paper›PMID 41860832›Full record

ArticlePloS one2026

Analysis of 6-week mortality and influencing factors in patients with liver cirrhosis and portal vein thrombosis complicated by acute gastrointestinal bleeding.

Junli Zhang, Ling Feng

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Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

2 authors.

Junli ZhangDepartment of Gastroenterology and Hepatology, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, PR China.ORCID https://orcid.org/0009-0008-8559-4093
Ling FengDepartment of Neurology, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, PR China.ORCID https://orcid.org/0000-0002-1792-3501

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the 6-week mortality of acute gastrointestinal bleeding in patients with liver cirrhosis and portal vein thrombosis and to analyze its influencing factors.

methodsThis was a retrospective study. We retrospectively screened 232 patients with liver cirrhosis and portal vein thrombosis complicated by acute gastrointestinal bleeding who were admitted to West China Hospital of Sichuan University from January 1,2020 to November30,2022. Of the 232 patients, 75 had their first bleeding. Additionally, the patients were divided into a mortality group (n = 34) and a non-mortality group (n = 198) based on whether they died within 6 weeks of the onset of gastrointestinal bleeding. Baseline general information, laboratory indicators, and other clinical data of the two groups were compared, and the independent risk factors for 6-week mortality in patients with liver cirrhosis and portal vein thrombosis complicated by acute gastrointestinal bleeding were analyzed.

resultsThere were significant differences between the two groups in terms of the etiology of liver cirrhosis, HCC, 5-day treatment failure rate (8.62%), TBiL, ALT, BUN, Na, eGFR, DBiL, AST, GGT, ALP, CR, WBC, PLT, and PT(p < 0.05). Multivariate logistic regression analysis revealed that elevated ALP levels showed a positive association with 6-week mortality [OR=1.01, 95% CI (1.01, 1.01), p < 0.01] and 5-day treatment failure showed a positive association with 6-week mortality [OR=11.27, 95% CI (3.45, 36.81),p < 0.01].

conclusionElevated ALP and 5-day treatment failure were found to be independent risk factors for 6-week mortality in patients with cirrhosis and portal vein thrombosis complicated by acute gastrointestinal bleeding.

Indexed as

Gastrointestinal HemorrhageLiver CirrhosisPortal VeinVenous ThrombosisAcute DiseaseAdultAgedChinaFemaleHumansMaleMiddle AgedRetrospective StudiesRisk Factors

Identifiers

PMID41860832
PMCPMC13004350

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