Evidence map›Paper›PMID 41860824›Full record

ArticlePloS one2026

Malaria parasitemia and its association with liver function parameters, and lipid profile among malaria-infected adult patients in western Ethiopia: A comparative cross-sectional study.

Nigus Checkole, Waqtola Cheneke, Temam Ibrahim, Shiferaw Bekele, Birhane Teklay, Mebrahtu Tefera, Ataklti Gebretsadik, Bisrat Fikadu, Getachew Belay Kassahun

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Nigus CheckoleDepartment of medical laboratory science, College of medicine and Health science, Adigrat University, Adigrat, Tigray, Ethiopia.
Waqtola ChenekeDepartment of clinical chemistry, School of Medical Laboratory Science, Institute of Health science, Jimma University, Jimma, Oromia, Ethiopia.
Temam IbrahimDepartment of clinical chemistry, School of Medical Laboratory Science, Institute of Health science, Jimma University, Jimma, Oromia, Ethiopia.
Shiferaw BekeleDepartment of clinical chemistry, School of Medical Laboratory Science, Institute of Health science, Jimma University, Jimma, Oromia, Ethiopia.
Birhane TeklayDepartment of Midwifery, College of medicine and Health science, Raya University, Maichew, Tigray, Ethiopia.ORCID https://orcid.org/0000-0003-0379-2616
Mebrahtu TeferaDepartment of medical laboratory science, College of medicine and Health science, Adigrat University, Adigrat, Tigray, Ethiopia.
Ataklti GebretsadikDepartment of Pharmacy, College of medicine and Health Science, Adigrat University, Adigrat, Tigray, Ethiopia.
Bisrat FikaduDepartment of Medical Laboratory Sciences, College of Medicine and Health Science, Welkite University, Welkite, Ethiopia.
Getachew Belay KassahunDepartment of medical laboratory science, College of medicine and Health science, Adigrat University, Adigrat, Tigray, Ethiopia.ORCID https://orcid.org/0000-0002-9750-527X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMalaria poses a public health problem because it manifests anemia, renal and liver dysfunction, Jaundice, and dyslipidemia. Therefore, the study aimed to assess malaria parasitemia and its association with liver function parameters and lipid profile in Assosa town, Ethiopia from December 23/2021 to March 4/2022.

methodsInstitution-based comparative cross-sectional study was conducted among 302 study participants (151 study groups and 151comparison group) who were selected by consecutive sampling technique. Socio-demographic and clinical data were collected using structured questionnaires and entered using Epi Data version 4.6. Venous blood specimen was collected from all study individuals and tested for selected parameters by Cobas 311 automated clinical chemistry analyzer. Descriptive statistics, Pearson's Chi-square, t-test, and ANOVA were used to assess the association using STATA software version 14.

resultsA total of 302 study participants comprising 212(70.2%) males were included. Majority (70.86%) of malaria patients were infected with P. falciparum (The parasitic densities were reported with 30.46%, 46.36%, and 23.18% for low, moderate, and high parasitemia, respectively. The mean value of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and serum bilirubin was significantly higher in malaria patients than in apparently healthy controls (p < 0.001). However, the mean value of total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol was significantly lower in malaria patients than controls (P < 0.05). CONCLUSION AND RECOMMENDATION: Liver function tests and lipid profile should be assessed for malaria infected individuals in order to prevent malaria complications.

Indexed as

LipidsLiverMalariaMalaria, FalciparumParasitemiaAdolescentAdultAlanine TransaminaseAspartate AminotransferasesBilirubinCross-Sectional StudiesEthiopiaFemaleHumansLiver Function TestsMaleAlanine TransaminaseAspartate AminotransferasesBilirubinLipids

Identifiers

PMID41860824
PMCPMC13004395

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