Evidence map›Paper›PMID 41860791›Full record

ArticleCancer science2026

Expression of Glycoprotein B (gB) Correlates With Poor Prognosis in Nasopharyngeal Carcinoma.

Shigetaka Komura, Satoru Kondo, Hideya Kawasaki, Shinji Watanabe, Satoshi Yamada, Hirotomo Dochi, Han Gia Nguyen, Isao Ohta, Makiko Moriyama-Kita, Masaki Fukuyo and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Shigetaka KomuraDivision of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.ORCID https://orcid.org/0009-0000-1462-7507
Satoru KondoDivision of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.ORCID https://orcid.org/0000-0002-9066-0787
Hideya KawasakiNanoSuit Research Laboratory, Division of Preeminent Bioimaging Research, Institute of Photonics Medicine, Hamamatsu University School of Medicine, Japan.
Shinji WatanabeWPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kanazawa, Japan.
Satoshi YamadaDepartment of Otolaryngology/Head and Neck Surgery, Hamamatsu University School of Medicine, Shizuoka, Japan.
Hirotomo DochiDivision of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.ORCID https://orcid.org/0000-0001-5711-7240
Han Gia NguyenDivision of Nano Life Science, Graduate School of Frontier Science Initiative, Kanazawa University, Kanazawa, Japan.
Isao OhtaAdvanced Research Facilities and Services, Preeminent Medical Photonics Education and Research Center, Hamamatsu University School of Medicine, Shizuoka, Japan.
Makiko Moriyama-KitaDivision of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Masaki FukuyoDepartment of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Kousho WakaeDepartment of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.ORCID https://orcid.org/0000-0001-7767-6795
Yuki KitagawaDivision of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.ORCID https://orcid.org/0009-0007-5197-1025
Harue MizokamiDivision of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Luyao LiuDivision of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Nobuyuki HiraiDivision of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Eiji KobayashiDivision of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Takayoshi UenoDivision of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Yosuke NakanishiDivision of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Kazuhira EndoDivision of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Hisashi SugimotoDivision of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Naohiro WakisakaDepartment of Otolaryngology, National Hospital Organization Kanazawa Medical Center, Kanazawa, Japan.
Rikinari HanayamaDepartment of Immunology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
Kiyoshi MisawaDepartment of Otolaryngology/Head and Neck Surgery, Hamamatsu University School of Medicine, Shizuoka, Japan.
Atsushi KanedaDepartment of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID https://orcid.org/0000-0002-6980-5515
Tomokazu YoshizakiDivision of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.ORCID https://orcid.org/0000-0002-2420-5540

Funding

Ministry of Education, Culture, Sports, Science and Technology 16H05480Ministry of Education, Culture, Sports, Science and Technology 17H01590the Japan Science and Technology AgencySPRING JPMJSP2135
6 · The paper itself

Abstract

The Epstein-Barr virus (EBV) has two life cycles: latent and lytic. Previously, the latent cycle had been considered more relevant to EBV-associated epithelial malignancies, including nasopharyngeal carcinoma (NPC), whereas the lytic cycle, which ultimately leads to the death of host cells, had not been considered. However, recent studies have revealed that abortive lytic infections, in which the lytic cycle halts midway, avoids host cell death and contributes to tumorigenesis and tumor growth. However, the progression of the lytic cycle in NPC and its association with viral replication remain unclear. This study aimed to perform morphological analyses of EBV-positive NPC cell lines and clinical NPC biopsy samples using transmission electron microscopy, NanoSuit-correlative light and electron microscopy, and scanning ion conductance microscopy. Virion-like particles were observed in lytically induced EBV-positive NPC cell lines using time-lapse imaging to capture their release. These particles were also detected in clinical NPC samples using electron microscopy. Immunohistochemical analysis with the glycoprotein B (gB) antibody revealed a strong association between gB expression and poor prognosis. In conclusion, lytic infections with EBV replication occur in NPC, and the frequency of EBV replication is significantly associated with poor prognosis.

Indexed as

Epstein-Barr Virus InfectionsHerpesvirus 4, HumanNasopharyngeal CarcinomaNasopharyngeal NeoplasmsViral Envelope ProteinsAdultAgedBiopsyCell Line, TumorFemaleHumansImmunohistochemistryMaleMiddle AgedPrognosisProgression-Free Survivalglycoprotein B, human herpesvirus 4Viral Envelope ProteinsEpstein–Barr virusgBlytic infectionnanosuitnasopharyngeal carcinoma

Identifiers

PMID41860791
PMCPMC13134505

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.