Evidence map›Paper›PMID 41860721›Full record

ArticleEuropean geriatric medicine2026

Blood and urine cell-free circulating DNA in older adults with sarcopenia: a hypothesis-generating study.

Yasuko Yoshida, Takashi Shida, Masato Yonamine, Yosuke Osuka, Kazuhiro Takekoshi, Hiroyuki Sasai

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Article in European geriatric medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yasuko Yoshida *Faculty of Medical Technology, Department of Medical Technology, Niigata University of Pharmacy and Medical and Life Sciences, 265-1 Higashizima, Akiha-Ku, Niigata, 956-8603, Japan. yyoshida@nupals.ac.jp.ORCID http://orcid.org/0009-0006-8872-686X
Takashi Shida *Research Team for Promoting Independence and Mental Health, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.
Masato YonamineFaculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Yosuke OsukaResearch Team for Promoting Independence and Mental Health, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.
Kazuhiro TakekoshiFaculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Hiroyuki SasaiResearch Team for Promoting Independence and Mental Health, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.

Funding

Kaken Pharmaceutical JP21K17663
6 · The paper itself

Abstract

purposeThis preliminary study evaluated effect sizes of differences in circulating cell-free DNA (cfDNA) levels in blood and urine between older adults with and without sarcopenia.

methodsThis was a subanalysis of the 2021 Itabashi Longitudinal Study on Aging. Twenty-four participants were selected conveniently and classified using the Asian Working Group for Sarcopenia (AWGS) 2019 criteria (sarcopenia, N = 12; non-sarcopenia, N = 10). Plasma and urinary cfDNA were quantified by real-time quantitative polymerase chain reaction (qPCR).

resultscfDNA measures showed substantial inter-individual variability, and no clear between-group differences were observed. Plasma cfDNA demonstrated a moderate positive correlation with skeletal muscle mass index (r = 0.43, p = 0.03), but the clinical relevance remains uncertain given the small sample size.

conclusionsLarger, well-powered longitudinal studies are needed to clarify whether cfDNA, including mitochondrial and nuclear components, can serve as a biomarker of muscle health and sarcopenia risk in older adults.

Indexed as

Cell-Free Nucleic AcidsSarcopeniaAgedAged, 80 and overAgingBiomarkersFemaleHumansLongitudinal StudiesMaleMuscle, SkeletalBiomarkersCell-Free Nucleic AcidsBiomarkerCell-free DNAPreliminary studySarcopenia

Identifiers

PMID41860721

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