SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Effectiveness of exercise interventions in patients with colorectal cancer during adjuvant chemotherapy: a systematic review and meta-analysis.
Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Genetic Insights into Interleukin-13 Polymorphisms in Colorectal Cancer Risk and Progression.Cancer genomics & proteomicsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWhile some studies have investigated the effectiveness of exercise interventions during adjuvant chemotherapy in cancer patients, the findings are inconclusive. This systematic review and meta-analysis aimed to quantify the effectiveness of exercise interventions specifically in patients with colorectal cancer (CRC) during adjuvant chemotherapy.
methodsA comprehensive literature search was conducted using 6 electronic databases. Eligible studies included randomized controlled trials (RCTs), non-RCTs, single-arm intervention studies, and retrospective cohort studies that implemented structured exercise interventions. Exercise capacity, lower and upper extremity muscle strength, fatigue, pain, chemotherapy-induced peripheral neuropathy, anxiety, depression, and quality of life were defined as outcomes. A meta-analysis was performed to quantify the effectiveness of exercise interventions during adjuvant chemotherapy on each outcome. Additionally, the feasibility of the exercise interventions was investigated.
resultsNine studies met the inclusion criteria for the present systematic review. In the RCTs, exercise interventions during adjuvant chemotherapy significantly reduced fatigue (standardized mean difference [SMD]: -0.53 [95% confidence interval {CI}: -1.04, -0.01]) and depression (SMD: -0.34 [95% CI: -0.55, -0.13]), but had no significant effect on exercise capacity, lower and upper extremity muscle strength, pain, anxiety, and quality of life. Adherence to exercise interventions during adjuvant chemotherapy ranged from 58 to 100%. No adverse events were reported, or reporting was not provided.
conclusionsThis systematic review revealed that exercise interventions during adjuvant chemotherapy effectively reduce fatigue and depression in patients with CRC, though the effect may be small. The implementation of exercise interventions during adjuvant chemotherapy may be safe.
Indexed as
Identifiers
41860634What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.