ReviewLangenbeck's archives of surgery2026
Requirements for a successful implementation of liver transplantation as a treatment option for non-resectable colorectal liver metastases into clinical routine - a narrative review.
Review in Langenbeck's archives of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeColorectal cancer remains a major challenge for the global health care system. Many patients with colorectal cancer develop liver metastases (CRLM), and a certain proportion of these patients are neither eligible for surgical nor interventional treatment. Liver transplantation (LT) could be a curative treatment option for these patients.
methodsThis narrative review was based on a targeted literature search of the National Library of medicine (PubMED) to identify current publications investigating LT as a treatment option for patients with CRLM without local treatment options. The search term “colorectal AND liver transplantation” was used, and only original articles of the last ten years were included. Additionally, the ClinicalTrials.gov registry was screened for ongoing clinical trials in this field.
resultsA total of 6 studies were identified, along with 21 active clinical trials. LT was associated with higher survival rates compared to standard of care, e.g., 73.3% 5-year survival after LT plus chemotherapy vs. 9.3% after chemotherapy alone in the randomized TransMET trial. Candidates eligible for LT were most often identified based on stable, liver-limited disease under active chemotherapy, in addition to further strict selection criteria such as favorable molecular pathology and metabolic tumor volume. Patients were accordingly prioritized on the waiting list. Long-term follow-up revealed substantial recurrence rates across the studies, most occurring in the lungs. Despite these recurrences, overall survival remained superior to standard of care.
conclusionThe reviewed evidence suggests that LT should be considered as part of a multimodal treatment algorithm for highly selected patients with non-resectable CRLM. This paradigm shift has already translated into several ongoing trials on this subject. Policy adjustments in organ allocation and the development of structured programs are necessary to establish LT for CRLM patients in clinical routine.
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