ArticleJACC. Case reports2026
Is Aortic Regurgitation Associated With Long-Term Ergotamine Use?
Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Spectrum of Iatrogenic Valvular Heart Disease.JACC. Case reports · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere are various causes of acquired valvular heart disease (VHD), one of which is drug induced. CASE SUMMARY: A 62-year-old woman with long-term excessive use of ergotamine for migraines presented with a 1-month history of dyspnea and was admitted for chronic heart failure due to severe aortic regurgitation. Various medications were initiated in combination with dobutamine, resulting in symptomatic improvement. Under compensated heart failure, elective surgical aortic valve replacement was performed. Pathological examination of the excised valve revealed abnormal leaflet fibrosis, which is not usually observed in naturally degenerated aortic leaflets, suggesting ergotamine-induced valvular changes. DISCUSSION: This case involved severe aortic regurgitation due to aortic valve fibrosis, possibly caused by long-term ergotamine use, highlighting the need to consider drug-induced etiologies in the differential diagnosis of VHD. TAKE-HOME MESSAGE: The habitual use of ergotamine can cause valvular fibrosis as an adverse effect, potentially leading to VHD.
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