Evidence map›Paper›PMID 41860449›Full record

ArticleMolecular nutrition & food research2026

Unveiling the Probiotic Properties of Lacticaseibacillus paracasei UFTM 2.9 Through Probiogenomic Analysis.

Bárbara R Fonseca, Yasmin N V Sabino, Beatriz M O Rocha, Vasco A C Azevedo, Bertram Brenig, Siomar C Soares, Leandro N Lemos, Sheila C P D Luquetti, Aline D Paiva, Julliane D Medeiros and 1 more

Abstract read
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In one paragraph

Article in Molecular nutrition & food research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bárbara R FonsecaFederal University of Juiz de Fora, Minas Gerais, Juiz de Fora, Minas Gerais, Brazil.
Yasmin N V SabinoFederal University of Juiz de Fora, Minas Gerais, Juiz de Fora, Minas Gerais, Brazil.
Beatriz M O RochaFederal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Vasco A C AzevedoFederal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
Bertram BrenigGeorg August University Göttingen, Göttingen, Germany.
Siomar C SoaresFederal University of Triângulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil.
Leandro N LemosIlum School of Science, Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, São Paulo, Brazil, Campinas, São Paulo, Brazil.
Sheila C P D LuquettiFederal University of Juiz de Fora, Minas Gerais, Juiz de Fora, Minas Gerais, Brazil.
Aline D PaivaFederal University of Triângulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil.
Julliane D MedeirosFederal University of Juiz de Fora, Minas Gerais, Juiz de Fora, Minas Gerais, Brazil.
Alessandra B F MachadoFederal University of Juiz de Fora, Minas Gerais, Juiz de Fora, Minas Gerais, Brazil.ORCID 0000-0003-3972-7576

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFundação de Amparo à Pesquisa do Estado de Minas Gerais APQ 01128/22Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ 01597/22Programa de Pós-Graduação em Ciências Biológicas
6 · The paper itself

Abstract

Lactic acid bacteria (LAB) comprise a group of Gram-positive bacteria with biotechnological applications. LAB, including Lacticaseibacillus spp., are recognized as potential probiotics due to their ability to confer benefits to the host. Here we employ probiogenomic and in vitro analyses to characterize the probiotic potential of Lc. paracasei UFTM 2.9, a LAB that previously demonstrated probiotic properties in vitro. The draft genome of Lc. paracasei UFTM 2.9 comprises 127 contigs, totaling 3 216 252 base pairs, with a GC content of 46.20%. The bacteria showed metabolic versatility, growing in five carbon sources. A total of 170 genes potentially associated with probiotic characteristics were identified, with functions linked to stress resistance (n = 106), adhesion (n = 12), biosynthesis of vitamins (n = 10), and others. No virulence genes or CRISPR elements were detected, and two phages were identified in Lc. paracasei UFTM 2.9. Gene clusters encoding bacteriocins were detected and confirmed in vitro. Lc. paracasei UFTM 2.9 inhibited all indicator bacteria tested (n = 12), including strains of Listeria innocua, Staphylococcus aureus, Streptococcus agalactiae, and Escherichia coli. The results indicate the potential use of Lc. paracasei UFTM 2.9 as a probiotic, considering its genetic potential to express traits of interest and survive in the gastrointestinal tract (GIT).

Indexed as

Genome, BacterialLacticaseibacillus paracaseiProbioticsBacteriocinsMultigene FamilyBacteriocinsLABLc. paracaseiprobiotics

Identifiers

PMID41860449
PMCPMC13004014

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.