ArticlePediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2026
Viral and Host-Related Factors in the Nasal Inflammatory Response to Critical Bronchiolitis in Infants and Children.
Article in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesWe aimed to evaluate the inflammatory cytokine response in children with critical bronchiolitis. Our secondary aims included: 1) understanding differences in inflammatory profiles between respiratory syncytial virus (RSV), rhinovirus, and polyviral infection, and 2) examining the association between clinical risk factors and the host inflammatory response.
designA single-center, prospective cohort study of PICU patients with critical bronchiolitis.
settingMedium-sized academic PICU from October 2021 to July 2024. PATIENTS: Forty-two patients with critical bronchiolitis and nine healthy control patients.
interventionsNone. MEASUREMENTS AND MAIN
resultsNasal aspirates were obtained and cytokines measured by enzyme-linked immunosorbent assay. The influence of viral type and host factors was assessed by nonparametric testing. In an exploratory analysis, cells from the nasal aspirates of a select group of patients underwent next-generation RNA sequencing (RNASeq). The nasal samples from patients with critical bronchiolitis exhibited an increase in interferons, type 1, and type 2 immunity-related cytokines. We did not identify differences in cytokine levels when comparing patients with rhinovirus to those with RSV infection. Patients with multiple (> 1) bronchiolitis admissions exhibited lower levels of inflammatory cytokines compared with patients during their first bronchiolitis admission. Using RNASeq, a subgroup of patients with rhinovirus or RSV exhibited similar upregulation of gene pathways associated with leukocyte chemotaxis, interferon signaling, and tumor necrosis factor superfamily cytokines compared with healthy controls. Pathways associated with ciliary function were downregulated compared with controls with RSV inducing a more pronounced downregulation than rhinovirus.
conclusionsThese data demonstrate that patients with critical bronchiolitis exhibit a robust host inflammatory response independent of viral etiology. Our exploratory transcriptomic analysis showed upregulation of proinflammatory genes and downregulation of ciliary genes consistent with clinical characteristics of these patients at the bedside.
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