Evidence map›Paper›PMID 41860304›Full record

ArticlePediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2026

Plasma Linoleic Acid Is Associated With Pediatric Sepsis Phenotype and Acute Kidney Injury.

Ivan E Saraiva, Dana Y Fuhrman, Kate F Kernan, Hyun-Jung Park, Xinlei Chen, Robert A Berg, Kathleen L Meert, Murray Pollack, Mark Hall, Christopher Newth and 4 more

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In one paragraph

Article in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ivan E SaraivaProgram for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.ORCID 0000-0002-8957-1576
Dana Y FuhrmanDivision of Pediatric Critical Care Medicine, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.
Kate F KernanDivision of Pediatric Critical Care Medicine, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.
Hyun-Jung ParkDepartment of Biostatistics, School of Public Health, University of Pittsburgh, Pittsburgh, PA.
Xinlei ChenDepartment of Biostatistics, School of Public Health, University of Pittsburgh, Pittsburgh, PA.
Robert A BergDivision of Pediatric Critical Care Medicine, Department of Anesthesiology, Children's Hospital of Philadelphia, Philadelphia, PA.
Kathleen L MeertDivision of Pediatric Critical Care Medicine, Department of Pediatrics, Children's Hospital of Michigan, Detroit, MI.
Murray PollackDivision of Pediatric Critical Care Medicine, Department of Pediatrics, Children's National Hospital, Washington, DC.
Mark HallDivision of Pediatric Critical Care Medicine, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH.
Christopher NewthDivision of Pediatric Critical Care Medicine, Department of Anesthesiology, Children's Hospital Los Angeles, Los Angeles, CA.
Rick HarrisonDivision of Critical Care Medicine, Department of Pediatrics, Mattelt Children's Hospital, Los Angeles, CA.
Thomas ShanleyDivision of Critical Care Medicine, Department of Pediatrics, Mott Children's Hospital, Ann Arbor, MI.
Joseph A CarcilloDivision of Pediatric Critical Care Medicine, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.
Hernando GómezProgram for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.

Funding

Data Coordinating Center for the Collaborative Pediatric Critical Care Research NetworkU01HD049934 · NICHD · UNIVERSITY OF UTAH · PI DEAN, JONATHAN MICHAEL · 2005 to 2020
$35.2M
Multidisciplinary Training in Critical Care Outcomes ResearchT32HL007820 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Timothy D Girard, Jeremy M Kahn · 1996 to 2026
$6.4M
Inflammation Phenotypes in Pediatric Sepsis Induced Multiple Organ Failure RenewalR01GM108618 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOSEPH A CARCILLO · 2014 to 2026
$5.4M
Physiologically Guided Ventilator Strategies in ChildrenU10HD050012 · NICHD · CHILDREN'S HOSPITAL OF LOS ANGELES · PI NEWTH, CHRISTOPHER JOHN · 2005 to 2014
$3.7M
Neurodevelopmental Outcome after Cardiac Intensive CareU10HD049981 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI WESSEL, DAVID LLOYD · 2005 to 2014
$3.7M
Collaborative Pediatric Critical Care Research NetworkU10HD050096 · NICHD · WAYNE STATE UNIVERSITY · PI MEERT, KATHLEEN L. · 2005 to 2014
$3.2M
Metoclopramide prevents PICU nosocomial infectionU10HD049983 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CARCILLO, JOSEPH A · 2005 to 2014
$3.1M
Renewal Application for the Childrens Hospital of Pittsburgh Collaborative Pediatric Critical Care Research Network SiteUG1HD049983 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CARCILLO, JOSEPH A · 2015 to 2020
$1.6M
Pediatric Critical Care Research Network at Children's Hospital of PhiladelphiaU10HD063108 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI BERG, ROBERT ALLEN · 2010 to 2014
$1.4M
Predicting Morbidity from Pediatric Critical CareU10HD063114 · NICHD · PHOENIX CHILDREN'S HOSPITAL · PI DALTON, HEIDI J, LUND, DENNIS P · 2010 to 2014
$1.4M
Collaborative Pediatric Research Critical Care Network(U10)U10HD063106 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHANLEY, THOMAS P. · 2010 to 2014
$1.3M
Genetic Variants of Immune Dysregulation and Thrombotic Microangiopathy in Severe Pediatric Sepsis Induced Organ DysfunctionK23GM148827 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Kathryn MARY Kernan · 2023 to 2026
$652k
NHLBI NIH HHS T32 HL007820NICHD NIH HHS U01 HD049934NICHD NIH HHS U10 HD049981NICHD NIH HHS U10 HD049983NICHD NIH HHS U10 HD050012NICHD NIH HHS U10 HD050096NICHD NIH HHS U10 HD063106NICHD NIH HHS U10 HD063108NICHD NIH HHS U10 HD063114NICHD NIH HHS UG1 HD049983NIGMS NIH HHS K23 GM148827NIGMS NIH HHS R01 GM108618
6 · The paper itself

Abstract

objectivesLinoleic acid (LA) is the most abundant polyunsaturated fatty acid in diet, and it is a precursor to inflammatory lipid mediators called oxylipins. The role of LA and its oxylipins in pediatric sepsis and organ injury is uncertain. Recently, pediatric sepsis phenotypes were described, with phenotype D characterized by the highest proportion of acute kidney injury (AKI), multiple organ failure, and risk of death. We aimed to test the hypothesis LA may play a role in sepsis-associated organ dysfunction. We therefore investigated whether increasing plasma LA and LA-derived lipoxygenase oxylipins are associated with sepsis phenotype D and with AKI in a cohort of critically ill children with sepsis.

designWe studied a subset of 108 patients from the Phenotyping Sepsis-Induced Multiple Organ Failure Study (PHENOMS) cohort by means of untargeted metabolomics of heparinized plasma samples. Primary outcome was phenotype group. Key secondary outcomes included AKI (defined as both creatinine > 1 mg/dL and oliguria < 0.5 mL/kg/hr), other organ dysfunctions, and hospital mortality. Patients were followed up until discharge or 28 days.

settingICU. PATIENTS: One hundred eight patients with sepsis.

interventionsNone. MEASUREMENTS AND MAIN

resultsHigher LA levels were associated with sepsis phenotype D as compared with phenotypes A-C (odds ratio [OR], 1.67; 95% CI, 1.05-2.65; p = 0.03). LA-derived oxylipins 9-hydroxyoctadecadienoic acid and 13-hydroxyoctadecadienoic acid (9-HODE/13-HODE) were also associated with sepsis phenotype D (jointly reported in one variable; OR, 1.26; 95% CI, 1.01-1.57; p = 0.04). Higher LA showed a trend and 9-HODE/13-HODE was associated with AKI (OR, 1.52; 95% CI, 0.97-2.38; p = 0.07 and OR, 1.27; 95% CI, 1.03-1.56; p = 0.02, respectively). Neither LA nor oxylipins were associated with hospital mortality.

conclusionsLA levels and LA-derived lipoxygenase oxylipins are associated with pediatric sepsis phenotype D and AKI. These results support future mechanistic studies to investigate lipid metabolism in the pathophysiology of sepsis.

Indexed as

Acute Kidney InjuryLinoleic AcidSepsisAdolescentBiomarkersChildChild, PreschoolCritical IllnessFemaleHumansInfantMaleMultiple Organ FailurePhenotypeBiomarkersLinoleic Acidacute kidney injurylinoleic acidorgan dysfunctionoxylipinpolyunsaturated fatty acidsepsis phenotype

Identifiers

PMID41860304
PMCPMC13060013

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