Evidence map›Paper›PMID 41860029›Full record

ReviewInternational journal of molecular medicine2026

Targeting pyroptosis in renal fibrosis: From molecular mechanisms to therapeutic horizons (Review).

Yihuai Tian, Quwu Mushuo, Hui Fan, Hongwei Su, Jianchun Li, Qiong Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yihuai Tian *Institute of Integrated Chinese and Western Medicine, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.
Quwu Mushuo *Institute of Integrated Chinese and Western Medicine, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.
Hui FanDepartment of Nephrology, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.
Hongwei SuDepartment of Urology, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.
Jianchun LiResearch Center of Integrated Traditional Chinese and Western Medicine, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.
Qiong ZhangInstitute of Integrated Chinese and Western Medicine, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyroptosis, an inflammatory form of lytic programmed cell death intricately linked to innate immunity, is a pivotal driver of renal fibrosis. Its dysregulated activation initiates a self‑amplifying cycle of chronic inflammation and extracellular matrix deposition, ultimately leading to renal failure. The present review integrates current knowledge primarily from preclinical

Indexed as

KidneyKidney DiseasesPyroptosisAnimalsFibrosisGasderminsHumansNLR Family, Pyrin Domain-Containing 3 ProteinSignal TransductionGasderminsNLR Family, Pyrin Domain-Containing 3 Proteincrosstalkpyroptosisrenal fibrosissignaling pathwaytherapeutic strategies

Identifiers

PMID41860029
PMCPMC13034895

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.