Evidence map›Paper›PMID 41859929›Full record

ReviewRNA biology2026

Reading the SINEs - functionality in noncoding RNA 'cheap genes'.

Eitan Erez Zahavi, Mike Fainzilber

Abstract readReview
In one paragraph

Review in RNA biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Eitan Erez ZahaviDepartments of Molecular Neuroscience and Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0002-9555-2654
Mike FainzilberDepartments of Molecular Neuroscience and Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0001-8173-8557

Funding

Mechanism and activity of beta-lactam resistant enzymes in E. faecium and E. faecalisR01AI141522 · NIAID · RHODE ISLAND HOSPITAL · PI Wolfgang Peti, Louis B. Rice · 2019 to 2026
$5.1M
NIAID NIH HHS R01 AI141522
6 · The paper itself

Abstract

SINEs (Short Interspersed Nuclear Elements) are a class of retrotransposons, among the most prolific and transcriptionally active groups of repetitive elements. Rodent B1/B2-SINEs and primate Alu RNAs are upregulated in stress responses such as cellular heat shock or upon viral infection. Here, we review recent findings demonstrating that SINE RNAs have also integrated as adaptive regulators of gene expression in different biological contexts, particularly in nervous system lesion, degeneration and remodelling. These integral roles in physiological processes reinforce the concept that SINEs provide 'cheap genes' for evolutionary adaptation of non-coding RNA to biological function.

Indexed as

RNA, UntranslatedShort Interspersed Nucleotide ElementsAlu ElementsAnimalsEvolution, MolecularGene Expression RegulationHumansRNA, UntranslatedAlunerve regenerationneurodegenerationneuronNon-coding RNASINE

Identifiers

PMID41859929
PMCPMC13034634

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.