Observational studyInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2026
Comparison of cerebro-placental-uterine ratio between patients with gestational diabetes mellitus and healthy pregnant women: A prospective tertiary center observational study.
Observational study in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThe aim of this study was to evaluate the cerebroplacental ratio (CPR) and the cerebroplacental-uterine ratio (CPUR) in pregnancies complicated by gestational diabetes mellitus (GDM) and to determine the role of these indices in predicting adverse perinatal outcomes.
methodsThis prospective, single-center observational study was conducted at a tertiary care institution between August 2024 and January 2025. A total of 117 pregnant women were enrolled, including 64 with GDM (group 1) and 53 without GDM (group 2). The GDM group was further subdivided according to treatment modality (diet-controlled vs. insulin-treated). Doppler parameters, as well as maternal and fetal outcomes, were compared between the groups.
resultsIn the GDM group, body mass index (BMI) (P < 0.001), cesarean delivery rate (P = 0.037), and neonatal intensive care unit (NICU) admissions (P = 0.010) were significantly higher, whereas gfestational age at delivery (P = 0.016), first and fifth minute Apgar scores, and umbilical cord PH were significantly lower (P < 0.05). The umbilical artery pulsatility index (UA-PI) was significantly elevated in the GDM group, while CPR (P < 0.001) and CPUR (P < 0.001) were significantly lower. Both CPR and CPUR were significant predictors of adverse fetal outcomes. In the study group, the receiver operating characteristic analysis for CPR predicting NICU admission yielded an optimal cut-off value of 1.45 (area under the curve [AUC] = 0.725; P = 0.001), with 69.2% sensitivity and 69.2% specificity. For CPUR, the optimal cut-off was 1.37 (AUC = 0.761; P = 0.001), with 73.1% sensitivity and 72.5% specificity.
conclusionIn patients with GDM, both CPR and CPUR were significantly lower compared to healthy pregnancies, and CPUR was shown to be a clinically useful predictor of adverse fetal outcomes.
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