Reduction in Synaptic Vesicle Protein Abundance but Increased Amounts of Nsg2 and Lpcat1 in Cerebral Cortices Without the Endosomal SNARE Proteins Vti1a and Vti1b.

Julia Gottschalk, Katharina Kotschnew, Julia Hahn, Thomas Patschkowski, Gabriele von Fischer von Mollard

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Article in Proteomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

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2 · The registry

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Julia GottschalkBiochemistry III, Department of Chemistry, Bielefeld University, Bielefeld, Germany.

Katharina KotschnewBiochemistry III, Department of Chemistry, Bielefeld University, Bielefeld, Germany.

Julia HahnProteom and Metabolom Research, Department of Biology, Bielefeld University, Bielefeld, Germany.

Thomas PatschkowskiTechnology Platform Genomics, CeBiTec, Bielefeld University, Bielefeld, Germany.

Gabriele von Fischer von MollardBiochemistry III, Department of Chemistry, Bielefeld University, Bielefeld, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Absence of the endosomal SNAREs vti1a and vti1b results in perinatal death and severe neuronal phenotypes in mice, while lack of one of these proteins results in minor phenotypes. Proteomic differences were investigated to obtain a deeper insight into processes in which vti1a and vti1b are involved. Here we applied a bottom-up shotgun proteomic approach to investigate the differences in wild-type, double heterozygous (DHET), vti1a

Indexed as

1-Alkyl-2-acetylglycerophosphocholine EsteraseCerebral CortexQb-SNARE ProteinsSynaptic VesiclesAnimalsEndosomesMiceMice, KnockoutProteomeProteomics1-Alkyl-2-acetylglycerophosphocholine EsteraseProteomeQb-SNARE Proteinsendosomemembrane trafficneurodegenerationproteomeSNARE

Identifiers

PMID41859820

DOI10.1002/pmic.70117

PMCPMC13106906

What OpenQuestion holds

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.