Trial reportFrontiers in physiology2026
Singing as training modality within pulmonary rehabilitation for COPD patients may enhance diaphragmatic function: a pilot RCT exploring impact on diaphragmatic mobility and thickness.
Trial report in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Introduction: Previous studies have suggested that singing training (ST) has been proposed as an engaging adjunct to pulmonary rehabilitation (PR) patients with COPD and may improve diaphragmatic function and alleviate symptoms. We aimed to explore whether ST (a structured, facilitator-led group singing-based intervention for COPD) was associated with improvements in diaphragmatic function and related clinical outcomes-including pulmonary function, exercise capacity, health-related quality of life, and psychological symptoms. We hypothesized that ST would improve diaphragmatic function and yield better patient-reported outcomes than health education (HE). Methods: In this randomized controlled trial (No. ChiCTR2100052874), we conducted with 40 stable COPD patients randomly assigned to either the ST group (n = 20) or the HE group (n = 20). Primary outcomes were ultrasound-derived diaphragmatic function (dynamic and static diaphragmatic excursion and diaphragmatic thickening fraction). Secondary outcomes included respiratory muscle strength (MIP/MEP), pulmonary function (FEV Results: Thirty-three patients completed follow-up (ST n = 18; HE n = 15). Compared with HE, ST produced greater improvement in dynamic diaphragmatic mobility (mean SD change 0.7 ± 0.6 vs. 0.1 ± 0.5 cm; difference 0.6 cm, 95% CI 0.1-1.3; Conclusion: In this pilot trial, ST was associated with improved diaphragmatic mobility and several clinically relevant outcomes compared with HE. These findings suggest that ST may serve as a relevant adjunct to pulmonary rehabilitation, however larger trials are needed to confirm efficacy. Clinical Trial Registration: https://www.chictr.org.cn/showproj.html?proj=135209.
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