Yeast species resource exploration and application in cell factories.

Meiling Zhang, Lin Xiang, Lei Qin, Haitao Yue, Chun Li

Abstract readReview

In one paragraph

Review in Synthetic and systems biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Meiling ZhangSchool of Intelligence Science and Technology, Xinjiang University, Urumqi, 830017, China.

Lin XiangKey Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Institute of Biochemical Engineering, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 102488, China.

Lei QinDepartment of Chemical Engineering, Tsinghua University, Beijing, 100084, China.

Haitao YueSchool of Intelligence Science and Technology, Xinjiang University, Urumqi, 830017, China.

Chun LiSchool of Intelligence Science and Technology, Xinjiang University, Urumqi, 830017, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Yeasts serve as important industrial hosts, contributing significantly to sustainable and green biomanufacturing efforts in the pursuit of global carbon neutrality, alongside other vital microorganisms. This review systematically summarizes recent advances in yeast cell factories, focusing on the exploration of yeast species resources, innovation in enabling technologies, and efficient biosynthesis strategies. The characteristics and industrial applications of commonly used industrial yeast chassis were reviewed. The advent of synthetic and systems biology tools has resulted in a significant enhancement of the efficiency of yeast manipulation and regulation. Key strategies for enhancing the titter, yield, and productivity (TRY) of yeast cell factories are elaborated, including dynamic regulation of metabolic pathways, transcription factor engineering for global metabolic regulation, GEM-driven optimization, dynamic trade-off between growth and production

Indexed as

BiomanufacturingEnabling technologiesMicrobial cell factorySynthetic biologyYeast species resources

Identifiers

PMID41859725

DOI10.1016/j.synbio.2025.12.007

PMCPMC12995575

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.