ArticleInternational journal of women's health2026
Development and Validation of an Early-Pregnancy Prediction Model for Indicated Preterm Birth Using Three-Dimensional Placental Ultrasound and Maternal Clinical Characteristics.
Article in International journal of women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To identify factors associated with indicated preterm birth (IPB) based on early pregnancy placental three-dimensional power Doppler ultrasound (3D-PDU) indices and maternal clinical characteristics, and to develop and validate a predictive model for IPB. Methods: A total of 458 singleton pregnancies from 2022 were retrospectively analyzed. Early pregnancy placental 3D-PDU indices Results: Multifactorial logistic regression identified a history of recurrent pregnancy loss, preterm birth history, and hypertensive disorders of pregnancy as independent risk factors for IPB, while early-pregnancy placental VFI was an independent protective factor. Based on the filter results, a nomogram model was plotted, which showed good discrimination (AUC: 0.900 [training set] and 0.882 [test set]). Hosmer-Lemeshow tests indicated good calibration ( Conclusion: The 3D-PDU indices, particularly VFI, may serve as valuable indicators of early placental perfusion. The nomogram developed in this study showed good predictive performance by integrating the early pregnancy placental 3D-PDU index (VFI) with maternal clinical characteristics, providing a potential tool for early identification of high-risk IPB pregnancies. Nonetheless, larger multicenter, prospective studies are needed to validate its applicability, and standardized protocols for 3D-PDU use should be established to ensure consistency.
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