Evidence map›Paper›PMID 41859581›Full record

ArticleCureus2026

Acute Nicotine Poisoning From Nicotine Pouch Use in Adolescents: A Case Report of Two Pediatric Cases.

Vasiliki Gketsi, Amvrosios Orfanidis, Aikaterini Gkrepi, Margarita Efthalia Ε Papasavva, Dimitra Florou, Ilektra Kyrochristou, Apostolia Balta, Vassiliki A Boumba

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In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vasiliki GketsiDepartment of Pediatrics, General Hospital of Ioannina "G. Hatzikosta", Ioannina, GRC.
Amvrosios OrfanidisDepartment of Forensic Medicine and Toxicology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, GRC.
Aikaterini GkrepiDepartment of Pediatrics, General Hospital of Ioannina "G. Hatzikosta", Ioannina, GRC.
Margarita Efthalia Ε PapasavvaDepartment of Pediatrics, General Hospital of Ioannina "G. Hatzikosta", Ioannina, GRC.
Dimitra FlorouDepartment of Forensic Medicine and Toxicology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, GRC.
Ilektra KyrochristouFaculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, GRC.
Apostolia BaltaFaculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, GRC.
Vassiliki A BoumbaDepartment of Forensic Medicine and Toxicology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, GRC.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute nicotine poisoning is a well-studied clinical condition in both adults and children. However, poisoning resulting from the absorption of nicotine through the oral mucosa, as with modern nicotine pouches, is a complex and emerging field of medical research. This process is influenced by various factors that require further investigation, especially in the vulnerable age group of minors under 18 years, for whom the use of these products is legally prohibited. Based on two incidents of acute nicotine poisoning following the use of nicotine pouches in pediatric patients, the clinical and toxicological aspects of such conditions are discussed. The incidents concerned a 15-year-old boy and a 13-year-old girl. Both patients experienced symptoms consistent with nicotine poisoning, such as dizziness, nausea, vomiting, and loss of consciousness, which appeared within 90 and 20 minutes, respectively, after using the products. Both patients improved with supportive care. Samples taken upon their admission for toxicology testing confirmed acute nicotine poisoning with serum nicotine levels of 134 ng/ml and 266 ng/ml, respectively. Nicotine pouches, while promoted as a reduced-harm alternative to tobacco products for adult smokers, are not risk-free products. The distinction between "reduced harm" and "risk-free" is crucial and must be a central point in the discussion on legislative regulation and public health.

Indexed as

acute nicotine intoxicationadolescentschildrennicotine pouchessnuz

Identifiers

PMID41859581
PMCPMC12997380

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.