Contribution of rare variation to degenerative orthopedic diseases.

Christian Anker-Hansen, Eric Manderstedt, Christina Lind-Halldén, Christer Halldén, Bengt Zöller

Abstract read

In one paragraph

Article in Osteoarthritis and cartilage open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Christian Anker-HansenCenter for Primary Health Care Research, Department of Clinical Sciences, Lund University and Region Skåne, Jan Waldenströms gata 35, Malmö, 20502, Sweden.

Eric ManderstedtCenter for Primary Health Care Research, Department of Clinical Sciences, Lund University and Region Skåne, Jan Waldenströms gata 35, Malmö, 20502, Sweden.

Christina Lind-HalldénCenter for Primary Health Care Research, Department of Clinical Sciences, Lund University and Region Skåne, Jan Waldenströms gata 35, Malmö, 20502, Sweden.

Christer HalldénCenter for Primary Health Care Research, Department of Clinical Sciences, Lund University and Region Skåne, Jan Waldenströms gata 35, Malmö, 20502, Sweden.

Bengt ZöllerCenter for Primary Health Care Research, Department of Clinical Sciences, Lund University and Region Skåne, Jan Waldenströms gata 35, Malmö, 20502, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Degenerative orthopedic diseases (DODs) such as osteoporosis, osteoarthritis, spondylosis, spinal stenosis, and disc herniation are common disorders. Both common and rare genetic risk factors may contribute to DODs, but few large-scale whole-exome sequencing studies elucidating the contribution of rare variations to DODs have been published. The updated version of the Astra Zeneca portal (https://azphewas.com) was used to access gene collapsing analysis of rare variations for DODs. Method: One published UK Biobank portal: the updated Astra Zeneca portal based on whole genome sequencing (N = 484,111), was used to access gene collapsing analysis of rare qualifying variants (QVs) for fourteen DODs. A conservative threshold (p ≤ 5 × 10 Results: One previously osteoporosis-linked gene ( Conclusion: One established osteoporosis gene (

Indexed as

Exome sequencingGeneticsMolecular epidemiologyMusculoskeletal diseasesOsteoarthritisOsteoporosis

Identifiers

PMID41859529

DOI10.1016/j.ocarto.2026.100767

PMCPMC12996766

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.