Evidence map›Paper›PMID 41859514›Full record

ArticleChemical science2026

Single-position ligand modifications tune CB

Rudolf L Z Ganzoni, Miroslav Kosar, Yongqi Han, Rosa Maria Vitale, Pietro Amodeo, Xiaoting Li, Zhonghua Zha, Kacper J Patej, Bilal Kicin, Taddäus E N Strunden and 14 more

Abstract read
In one paragraph

Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Rudolf L Z GanzoniLaboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich Vladimir-Prelog-Weg 3 8093 Zürich Switzerland erickm.carreira@org.chem.ethz.ch.ORCID https://orcid.org/0000-0003-3510-6924
Miroslav KosarLaboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich Vladimir-Prelog-Weg 3 8093 Zürich Switzerland erickm.carreira@org.chem.ethz.ch.ORCID https://orcid.org/0000-0003-0166-7571
Yongqi HanFaculty of Medicine & Health Sciences, University of Nottingham, Centre of Membrane Proteins and Receptors (COMPARE) Nottingham NG7 2UH UK david.sykes@nottingham.ac.uk dmitry.veprintsev@nottingham.ac.uk.ORCID https://orcid.org/0009-0003-2425-5518
Rosa Maria VitaleInstitute of Biomolecular Chemistry, National Research Council Via Campi Flegrei 34 80078 Pozzuoli Italy.ORCID https://orcid.org/0000-0001-9243-1307
Pietro AmodeoInstitute of Biomolecular Chemistry, National Research Council Via Campi Flegrei 34 80078 Pozzuoli Italy.ORCID https://orcid.org/0000-0002-6439-7575
Xiaoting LiiHuman Institute, ShanghaiTech University Shanghai 201210 China.ORCID https://orcid.org/0000-0001-6431-3143
Zhonghua ZhaiHuman Institute, ShanghaiTech University Shanghai 201210 China.ORCID https://orcid.org/0009-0007-5615-2846
Kacper J PatejLaboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich Vladimir-Prelog-Weg 3 8093 Zürich Switzerland erickm.carreira@org.chem.ethz.ch.ORCID https://orcid.org/0009-0000-4000-1006
Bilal KicinLaboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich Vladimir-Prelog-Weg 3 8093 Zürich Switzerland erickm.carreira@org.chem.ethz.ch.ORCID https://orcid.org/0009-0001-7676-7115
Taddäus E N StrundenLaboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich Vladimir-Prelog-Weg 3 8093 Zürich Switzerland erickm.carreira@org.chem.ethz.ch.ORCID https://orcid.org/0009-0000-4165-3663
Lisa ReichertLaboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich Vladimir-Prelog-Weg 3 8093 Zürich Switzerland erickm.carreira@org.chem.ethz.ch.ORCID https://orcid.org/0000-0002-4684-8483
Uxía Gómez-BouzóLaboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich Vladimir-Prelog-Weg 3 8093 Zürich Switzerland erickm.carreira@org.chem.ethz.ch.ORCID https://orcid.org/0000-0001-9913-8728
Themiya P PereraFaculty of Medicine & Health Sciences, University of Nottingham, Centre of Membrane Proteins and Receptors (COMPARE) Nottingham NG7 2UH UK david.sykes@nottingham.ac.uk dmitry.veprintsev@nottingham.ac.uk.ORCID https://orcid.org/0009-0002-6873-5858
Kenneth AtzRoche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd 4070 Basel Switzerland uwe.grether@roche.com.ORCID https://orcid.org/0000-0002-2628-1619
Wolfgang GubaRoche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd 4070 Basel Switzerland uwe.grether@roche.com.ORCID https://orcid.org/0000-0002-3285-5957
Christian BartelmusRoche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd 4070 Basel Switzerland uwe.grether@roche.com.ORCID https://orcid.org/0000-0002-1527-4325
Raphael BiglerDepartment of Process Chemistry and Catalysis, F. Hoffmann-La Roche Ltd Basel 4070 Switzerland.ORCID https://orcid.org/0000-0003-1898-9112
Paolo TosattiDepartment of Process Chemistry and Catalysis, F. Hoffmann-La Roche Ltd Basel 4070 Switzerland.
Stephan BachmannDepartment of Process Chemistry and Catalysis, F. Hoffmann-La Roche Ltd Basel 4070 Switzerland.
Tian HuaiHuman Institute, ShanghaiTech University Shanghai 201210 China.ORCID https://orcid.org/0000-0002-6132-2068
David A SykesFaculty of Medicine & Health Sciences, University of Nottingham, Centre of Membrane Proteins and Receptors (COMPARE) Nottingham NG7 2UH UK david.sykes@nottingham.ac.uk dmitry.veprintsev@nottingham.ac.uk.ORCID https://orcid.org/0000-0002-6606-888X
Dmitry B VeprintsevFaculty of Medicine & Health Sciences, University of Nottingham, Centre of Membrane Proteins and Receptors (COMPARE) Nottingham NG7 2UH UK david.sykes@nottingham.ac.uk dmitry.veprintsev@nottingham.ac.uk.ORCID https://orcid.org/0000-0002-3583-5409
Uwe GretherRoche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd 4070 Basel Switzerland uwe.grether@roche.com.ORCID https://orcid.org/0000-0002-3164-9270
Erick M CarreiraLaboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich Vladimir-Prelog-Weg 3 8093 Zürich Switzerland erickm.carreira@org.chem.ethz.ch.ORCID https://orcid.org/0000-0003-1472-490X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cannabinoid receptor type 2 (CB

Identifiers

PMID41859514
PMCPMC12998566

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.