ArticleFrontiers in neurology
Latent-profile analysis of sleep disturbances, cognitive performance and neuropsychiatric symptoms reveals subtypes of Parkinson's disease.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03680170 (The Effect of Home-based Working Memory Updating Training on Cognition and Health in Patients With Parkinson's Disease), which is not on this map. Not yet cited in PubMed.
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The Effect of Home-based Working Memory Updating Training on Cognition and Health in Patients With Parkinson's Disease
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11 authors.
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Abstract
Objective: Given the clinical heterogeneity of Parkinson's disease (PD), identification of early -stage subgroups with shared non-motor symptom (NMS) profiles may clarify its pathophysiology. This study used latent-profile analyses (LPA) to define subgroups based on sleep disturbances, cognitive performance and neuropsychiatric symptoms, and examined dopaminergic function and brain volume differences between them. Methods: We analyzed data from 51 cognitively normal non-PD older adults and 105 early-stage PD participants from the iPARK trial, including 19 who underwent [ Results: LPA identified a two-cluster solution as the best fit. Group 1 ( Conclusion: These findings indicate clinically distinct subgroups in early-stage PD. Greater NMS burden is linked to impaired dopaminergic integrity, suggesting a potential neurobiological signature. Early identification of such subgroups may improve understanding of disease heterogeneity and support personalized management and interventions. Clinical trial registration: https://clinicaltrials.gov/study/NCT03680170?id=NCT03680170&rank=1, identifier (NCT03680170).
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