ArticleJournal of inflammation research2026
Associations of Systemic Inflammatory Response Index (SIRI) and Systemic Inflammatory Index (SII) with Cerebral Atherosclerosis.
Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Association of systemic inflammation response index with postoperative clinical outcomes among operated patients with aortic dissection: a systematic review with meta-analysis.Journal of thoracic disease · 2026Article
- Preoperative Systemic Immune-Inflammation Index as an Independent Predictor of Postoperative Wound Infection in Diabetic CABG Patients.Journal of cardiovascular development and disease · 2026Article
- Resolution of systemic inflammation in psoriasis following herring roe oil treatment: aFrontiers in medicine · 2026Article
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Authors and funding
7 authors.
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Abstract
Background: Atherosclerosis is a chronic inflammatory disease and a leading cause of stroke. Systemic inflammatory biomarkers are recognized predictors of coronary artery disease. However, their association with cerebral atherosclerosis remains unclear. This study aims to investigate the relationship between systemic inflammatory indices and cerebral atherosclerotic burden. Methods: A cohort of 5444 patients was enrolled. Cerebral atherosclerotic stenosis was evaluated using DSA, CTA, or MRA. The systemic inflammation response index (SIRI) and systemic immune-inflammation index (SII) were calculated and natural-log-transformed (ln-SIRI, ln-SII). The associations of ln-SIRI and ln-SII with the presence, severity (maximal stenosis degree) and extent (number of lesions) of cerebral atherosclerosis were evaluated using binary logistic regression, ordered logistic regression and restricted cubic spline models. Subgroup analyses were further conducted across clinically relevant strata to assess the consistency of these associations. Additionally, the diagnostic performance of both indices was evaluated using receiver operating characteristic (ROC) curve analysis. Results: Patients with cerebral atherosclerotic stenosis had significantly higher ln-SIRI (OR: 1.27, 95% CI: 1.19-1.35) and ln-SII (OR: 1.22, 95% CI: 1.15-1.30) compared to the non-stenosis group (both Conclusion: The systemic inflammatory indices ln-SIRI and ln-SII are significantly associated with the presence, severity and extent of cerebral atherosclerosis. These easily obtainable biomarkers may hold promise for improving risk stratification in cerebrovascular diseases.
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