ReviewJournal of inflammation research2026
Analysis of the Immunoinflammatory Microenvironment Characteristics of Epilepsy Based on Single-Cell Transcriptomics.
Review in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Artificial intelligence for automated detection of interictal epileptiform discharges: methodological progress, clinical evaluation, and neurodevelopmental context.Frontiers in cell and developmental biology · 2026Review
- APOE-Glia Crosstalk in Epilepsy: Mechanisms, Controversies, and Therapeutic Perspectives.Journal of inflammation research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epilepsy is a common neurological disease that affects a wide range of people and seriously impairs patients' quality of life and social adaptability. Neuroinflammation plays an important role in the pathogenesis of epilepsy. Glial cells, particularly astrocytes and their differentiated forms, as well as their interactions with other cell types, are critical in the process of neuroinflammation. A better understanding of the inflammatory mechanisms of epilepsy might facilitate the development of new therapeutic strategies. Single-cell RNA sequencing has provided new insights into the inflammatory microenvironment of the nervous system in epilepsy by enabling high-resolution characterization of cell type-specific gene expression and signaling pathways. In this review, we summarized the differentiation, interactions, and transcriptional dynamics of microglia, astrocytes, and neurons in epilepsy using single-cell sequencing data from patients and animal models, providing a basis for the development of new strategies for epilepsy treatment.
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Registered trials
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