Evidence map›Paper›PMID 41859354›Full record

ArticleSynthetic biology (Oxford, England)2026

Going beyond size: exploring the metabolic burden in

Marleen Beentjes, Ana-Sofia Ortega-Arbulú, Carina Meiners, Andreas Kremling, Katharina Pflüger-Grau

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Synthetic biology (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marleen BeentjesProfessorship of Systems Biotechnology, School of Engineering and Design, Technical University of Munich, Boltzmannstr. 15, 85748 Garching, Germany.
Ana-Sofia Ortega-ArbulúProfessorship of Systems Biotechnology, School of Engineering and Design, Technical University of Munich, Boltzmannstr. 15, 85748 Garching, Germany.
Carina MeinersProfessorship of Systems Biotechnology, School of Engineering and Design, Technical University of Munich, Boltzmannstr. 15, 85748 Garching, Germany.
Andreas KremlingProfessorship of Systems Biotechnology, School of Engineering and Design, Technical University of Munich, Boltzmannstr. 15, 85748 Garching, Germany.
Katharina Pflüger-GrauProfessorship of Systems Biotechnology, School of Engineering and Design, Technical University of Munich, Boltzmannstr. 15, 85748 Garching, Germany.ORCID https://orcid.org/0000-0002-8334-353X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In biotechnological applications, it is often necessary to introduce genes or entire pathways into a host cell, which can create a significant metabolic burden on the host, limiting productivity. In this study, we systematically investigated the physiological stress responses of

Indexed as

cellular capacityheterologous protein productionmetabolic burdenPseudomonas putidaresource allocation

Identifiers

PMID41859354
PMCPMC12998221

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.