ArticleFrontiers in pharmacology2026
Anticoagulant-free preparation of autologous platelet-rich plasma (PRP) / fluid platelet-rich fibrin (f-PRF): a pre-clinical comparative performance study.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Fibrin-Based Biomaterials in Wound Healing and Soft Tissue Regeneration: Biological Mechanisms and Clinical Applications.Gels (Basel, Switzerland) · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to validate and characterize the efficacy of a previously developed anticoagulant-free, single soft-spin centrifugation device for the preparation of autologous fluid-Platelet-Rich Fibrin (f-PRF). Introduction: f-PRF is generated via one-step soft-spin centrifugation of all blood to produce a platelet-enriched plasma for regenerative medicine use, without the need for additional chemical agents. This study validated the performance of a novel single soft-spin f-PRF preparation system. Methods: Sixteen healthy volunteers (94% female, ages 23-52) donated blood for a comparative analysis between Exprecell™ and Arthrex ACP Results: Exprecell™ yielded 20% more f-PRF volume (6.5-10.5 vs. 5.5-9.0 mL) with excellent cellular depletion (>99% erythrocyte, >95% leukocyte reduction). Platelet counts and function were similar between systems, with preserved Conclusion: These findings support the Exprecell™ single soft-spin methodology, demonstrating that anticoagulant-free f-PRF preparation achieves functional equivalence to conventional methods while providing a statistically significant increase in volume yield and procedural simplicity. The closed system design reduces contamination risk and Luer-lock compatibility facilitates integration into clinical workflows. Maintained
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