ArticleJuntendo medical journal2026
Patient-Reported Pain and Quality of Life Outcomes Following Iatrogenic Gallbladder Perforation During Laparoscopic Cholecystectomy.
Article in Juntendo medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Objectives: Intraoperative gallbladder perforation (IGP) is a frequent adverse event in laparoscopic cholecystectomy; however, its influence on patient-reported pain and health-related quality of life (HRQoL) is underinvestigated. This research evaluated the level of postoperative pain and HRQoL in patients with and without IGP. Materials Design: A longitudinal observational study was conducted on 300 adults who underwent elective laparoscopic cholecystectomy. Methods: The Brief Pain Inventory-Short Form (BPI-SF) and EQ-5D-5L assessed pain and HRQoL at 1 point in time (baseline) and at 2 points in time (3 and 6 months). Pearson's chi-square test, Mann-Whitney U test, Kruskal-Wallis test, and general linear models were used as statistical tests. Results: IGP was present in 80% of participants and was significantly associated with increased pain (r = 0.25, p < 0.001) and reduced HRQoL (r = -0.20, p < 0.001). HRQoL showed a moderate negative correlation with pain (r = -0.35, p = 0.001). Females complained about more pain and reduced QoL (p < 0.001). The IGP group also scored more in BPI-SF (baseline: 64.5 vs. 55.3; 6 months: 58.1 vs. 48.0) and continued to score lower in EQ-5D-5L. Even though pain and HRQoL improved over time, the difference between the IGP and non-IGP groups was substantial. Conclusion: Iatrogenic gallbladder perforation results in postoperative pain and a decrease in HRQoL that persisted up to six months postoperative. The use of preventive surgery and specific postoperative management is mandatory to enhance patient outcomes.
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