Evidence map›Paper›PMID 41859160›Full record

ArticleFrontiers in medicine2026

The role of cytokines in acute gastrointestinal injury: a prospective pilot study.

Yanhua Li, Youquan Wang, Lu Ke, Xinyu Li, Lingling Bao, Feng Zhang, Hongxiang Li, Dong Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Cheonggukjang-DerivedMetabolites · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yanhua LiDepartment of Critical Care Medicine, The First Hospital of Jilin University, Changchun, China.
Youquan WangDepartment of Critical Care Medicine, The First Hospital of Jilin University, Changchun, China.
Lu KeDepartment of Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Xinyu LiDepartment of Critical Care Medicine, The First Hospital of Jilin University, Changchun, China.
Lingling BaoDepartment of Critical Care Medicine, The First Hospital of Jilin University, Changchun, China.
Feng ZhangDepartment of Critical Care Medicine, The First Hospital of Jilin University, Changchun, China.
Hongxiang LiDepartment of Critical Care Medicine, The First Hospital of Jilin University, Changchun, China.
Dong ZhangDepartment of Critical Care Medicine, The First Hospital of Jilin University, Changchun, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to investigate the association between cytokines and the severity of acute gastrointestinal injury (AGI) in critically ill patients on day 3 after intensive care unit (ICU) admission. Methods: This was a single-center, prospective observational cohort study. We collected blood samples for 5 consecutive days and measured interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF- Results: A total of 116 patients were included in the final analysis. On day 1 after ICU admission, the levels of plasma biomarkers, such as IL-6, IL-10, TNF- Conclusion: In critically ill patients with AGI, the levels of cytokines on day 1 after ICU admission were positively associated with persistent intestinal failure during the early acute phase. Cytokines may partially mediate the relationship between intestinal injury and progression to persistent intestinal failure. Controlling the inflammatory response may represent a potential therapeutic strategy for acute gastrointestinal injury. Clinical trial registration: This study was registered with the Chinese Clinical Trial Registry on 21 February 2022 (Registration ID: ChiCTR2200056858).

Indexed as

acute gastrointestinal injurycritical illnesscytokinesD-lactateintensive care unitpersistent intestinal failure

Identifiers

PMID41859160
PMCPMC12996046

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.