ArticleFrontiers in immunology2026
isMap - immunological synapse map analysis program.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
T cell activation is initiated when T cells recognize their cognate antigen on the surface of antigen presenting cells (APCs). This triggers formation of a specialized membrane interface termed the immunological synapse (IS) which governs the spatial organization of the intercellular protein interactions ultimately determining the T cell response. While this is a fundamental process in adaptive immunity, tools for quantitative analysis and visualization of the IS molecular architecture are lacking. Here we present isMap, a computational framework for automated cell segmentation and quantification of various parameters related to T cell activation and IS formation on supported lipid bilayers (SLBs), including fluorescence intensity measurements, colocalization analysis and radial averaging. We validate isMap by confirming previous results showing that CD58 initially clusters with T cell receptor (TCR) before segregating into a distal ring during synapse maturation in activated CD8
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