Evidence map›Paper›PMID 41859104›Full record

ArticleFrontiers in immunology2026

Cloning, expression and characterisation of antigen-specific recombinant bat immunoglobulin from the black flying fox (

Jun Jet Hen, Ariel Isaacs, Benjamin Liang, Tony Schountz, Keith Chappell, Paul R Young, Naphak Modhiran, Daniel Watterson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jun Jet Hen *School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
Ariel Isaacs *School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
Benjamin LiangSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
Tony SchountzDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, United States.
Keith ChappellSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
Paul R YoungSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
Naphak ModhiranSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
Daniel WattersonSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bats are natural reservoir of viruses that cause severe disease in livestock and humans. Recent high-profile spillover events have directed significant attention towards the relationship between zoonotic viruses and antiviral immunity inherent to bats. Studies have highlighted that bats could harbour some deadly viruses without exhibiting outward symptoms. Various hypotheses have been proposed on how bats coexist with viruses, this includes dampened inflammation and altered innate immunity. However, there is limited literature on the humoral immune response in bats due to the scarcity of bat-specific reagents. To address this knowledge gap, we generated antigen-specific chimeric bat antibodies using recombinant antibody design techniques. This strategy involves combining the paratope of well-characterised antiviral antibodies with the IgG1 constant region of the black flying fox (

Indexed as

Antibodies, ViralChiropteraImmunoglobulin GAmino Acid SequenceAnimalsCloning, MolecularHumansRecombinant ProteinsAntibodies, ViralImmunoglobulin GRecombinant ProteinsantibodyantiviralbatChiropterafragment crystallizable regionglycoproteinIgGimmunoglobulin

Identifiers

PMID41859104
PMCPMC12995615

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.