ReviewInfection and drug resistance2026
Effects of Glutathione on Antibiotic Susceptibility and Resistance in Bacteria: A Comprehensive Review.
Review in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibiotic resistance has spread globally among bacterial pathogens, becoming a significant challenge to public health. Bacterial cells have an enormous capability to acquire various antibiotic resistance mechanisms. The effectiveness of many antibiotics relies on the intracellular redox balance and the bacteria's ability to mount stress responses. Glutathione (GSH) is an intracellular tripeptide antioxidant that significantly contributes to maintaining optimal redox balance, which may impact bacterial survival during antibiotic treatment. Neutralizing oxidative stress caused by antibiotics can reduce their effectiveness. However, alterations of the redox balance of GSH can impair normal cellular metabolism, making cells vulnerable. Altering the redox balance, either by depleting or increasing levels of GSH, can enhance the effectiveness of antibiotics. The influence of GSH on antibiotics varies depending on the bacterial species and the class of antibiotics used. Due to the vital role of GSH in antibiotic effectiveness, targeting bacterial GSH metabolism can be used as an adjunctive approach to overcome antibiotic resistance. This review summarizes the relationship between GSH and antibiotic susceptibility and resistance in bacteria.
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Registered trials
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