The effect of Wilms tumor 1-associated protein on ferroptosis and immune escape in non-small-cell lung cancer by mediating N6-methyladenosine modification of Twist1.

Xianghui Yang, Jiazhi Li, Yueyong Li, Min Li, Luogen Peng, Li Zhao, Lijuan Zou

Abstract read

In one paragraph

Article in CytoJournal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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7 authors.

Xianghui Yang *Department of Radiotherapy Oncology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.

Jiazhi Li *Department of Radiotherapy Oncology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.

Yueyong LiDepartment of Oncology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.

Min LiDepartment of Interventional Treatment, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.

Luogen PengDepartment of Oncology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.

Li ZhaoDepartment of Radiotherapy Oncology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.

Lijuan ZouDepartment of Radiotherapy Oncology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Non-small-cell lung cancer (NSCLC) is one of the most frequently occurring and aggressive cancers globally, but its complex molecular mechanisms remain only partially understood. This study investigated the effects of Wilms tumor 1-associated protein (WTAP) on NSCLC cell ferroptosis and immune escape through N6-methyladenosine (m6A) modification of twist family BHLH transcription factor 1 (Twist1). Material and Methods: Western blot and reverse transcription-quantitative polymerase chain reaction were used to assess Twist1 expression in NSCLC cell lines and its circular structure. Small interfering RNAs targeting Twist1 and WTAP were transfected into H2170 cells, and their effects on cell viability, apoptosis, ferroptosis markers (reactive oxygen species [ROS], malondialdehyde [MDA], and Fe Results: Twist1 was dramatically elevated in the NSCLC cell lines ( Conclusion: Twist1 is highly expressed in NSCLC. It promotes NSCLC progression by enhancing ferroptosis and immune escape. WTAP-mediated m6A methylation plays a critical role in regulating Twist1 expression. The WTAP/Twist1 axis may serve as a potential therapeutic target for NSCLC.

Indexed as

FerroptosisN6-methyladenosine modificationNon-small-cell lung cancerTwist1Wilms tumor 1-associated protein

Identifiers

PMID41859035

DOI10.25259/Cytojournal_114_2025

PMCPMC12997639

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