Evidence map›Paper›PMID 41859034›Full record

ArticleCytoJournal2026

Silencing C-X-C motif chemokine receptor inhibited autophagy of hippocampal neurons in epileptic mice by upregulating TWIK-related K

Hong Chen, Wenzeng Wang, Daqing Feng, Qun Chen, Tingting Guo, Qiannan Song

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PubMed Full text at PMC Publisher
In one paragraph

Article in CytoJournal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hong ChenDepartment of Pediatrics, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China.
Wenzeng WangGraduate School of Heilongjiang University of Chinese Medicine, Harbin, China.
Daqing FengDepartment of Pediatrics, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China.
Qun ChenDepartment of Laboratory, The People's Hospital of Acheng District, Harbin, China.
Tingting GuoDepartment of Pediatrics, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China.
Qiannan SongGraduate School of Heilongjiang University of Chinese Medicine, Harbin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Epilepsy is a neurological disease whose onset causes a variety of sequelae, reducing the standard of living. TWIK-related K Material and Methods: An animal model of epilepsy was established, and the Results: Compared with that in the normal group, TREK-1 expression decreased and CXCR2 expression increased significantly in the hippocampus of epileptic model mice ( Conclusion: Epileptic mice's hippocampal neuronal damage can be ameliorated by CXCR2 suppression. One possible explanation is that epileptic mice's hippocampus tissues express more TREK-1, which prevents excessive neuronal autophagy and lowers apoptosis.

Indexed as

AutophagyC-X-C motif chemokine receptorEpilepsyTWIK-related K+ channel 1

Identifiers

PMID41859034
PMCPMC12997642

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.