ArticleClinical ophthalmology (Auckland, N.Z.)2026
Assessment of Peripheral Anterior Synechiae Using Linear Gonio-Images Following Trabeculotomy with Trabectome.
Article in Clinical ophthalmology (Auckland, N.Z.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: To quantify peripheral anterior synechiae (PAS) extent after Trabectome surgery using automated gonioscopy (GS-1) and its effects on intraocular pressure (IOP) reduction. Patients and Methods: This retrospective, single-center study included patients who underwent Trabectome surgery and were followed for ≥ 6 months. GS-1 was performed at 6 and 12 months postoperatively to quantify PAS as the proportion of the angle circumference. Analysis of covariance (ANCOVA; linear regression) was performed at 6 and 12 months postoperatively, with IOP reduction rate, PAS extent, and preoperative IOP as the dependent variable, independent variable, and covariate, respectively. The 6- and 12-month PAS extents were compared using the Wilcoxon signed-rank test. The correlations of 6- and 12-month IOP reduction rates with age, preoperative IOP, preoperative score, and PAS extent were determined using Spearman's rank coefficients. Results: The data of 33 eyes (33 patients; 20 males; mean age, 68.5 ± 14.2 years) were analyzed. Trabectome surgery was performed as a standalone procedure for 28 patients and combined with cataract surgery for five. GS-1 revealed PAS in all eyes at 6 and 12 months. The mean PAS extents at 6 and 12 months were not significantly different at 40.16 ± 21.42% and 43.92 ± 20.68%, respectively (P = 0.286). Only preoperative IOP showed significant correlations with the 6- and 12-month IOP reduction rates (r = 0.641, 0.776; P = 0.002, < 0.001, respectively). ANCOVA revealed partial regression coefficients of 0.41 (P = 0.002) and 0.019 (P = 0.952) at 6 months and 0.37 (P = 0.014) and -0.180 (P = 0.623) at 12 months for preoperative IOP and PAS extent, respectively. Conclusion: Widespread PAS was detected by GS-1 at 6 and 12 months postoperatively. However, its effect on postoperative IOP reduction and prognosis appears limited. Moreover, the long-term effects remain unclear; therefore, further studies are warranted.
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